| Sunrise Course:
|
| From Bench to Bedside to
Bench: Translation of Animal Models to Clinical Practice &
From Clinical Practice to Animal Models |
| Organizers: Pia C. Maly
Sundgren, M.D., Ph.D.,
and Afonso C. Silva, Ph.D. |
| |
| Skill Level:
Intermediate |
| Tuesday - Friday, 4-7 May
2010 |
| 07:00 - 08:00 |
|
|
OVERVIEW |
In this four-hour course, each session
will focus on the translation of animal work to clinical practice
and vice versa, and the use of MRI to diagnose, estimate or get a
deeper insight in the outcome of the following pathologies:
-
Traumatic brain injury (TBI)
-
Polycystic kidney disease (PCKD)
-
Multiple sclerosis (MS)
-
Oncology Imaging (OI)
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|
Experimental findings and clinical work will be discussed
separately and combined in each session. The two speakers will
fine tune their findings to provide a full picture of what is
feasible and what is already translated to the clinical work-up,
and also how the clinical practice might translate into animal
models and improve insight into disease patho-physiology. |
|
|
|
EDUCATIONAL OBJECTIVES |
Upon completion of this course
participants should be able to:
- Describe the main MRI methods
used in experimental studies to understand the underlying
disease mechanisms;
- Identify what is known about the
underlying disease mechanisms, and which type of MRI
investigations could be used for diagnosis and clinical
investigation;
- Describe the main MRI methods
used in the clinical setting to diagnose the condition, and the
rationale behind this; and
- Make the translation from what
is - and can be - done in experimental studies to what can be
done clinically, and where animal models bring new insight to
disease.
|
|
| Tuesday
|
Traumatic Brain Injury
|
|
| |
Moderators: Pia C.
Maly Sundgren, M.D., Ph.D., and Afonso C. Silva, Ph.D.
|
| 07:00 |
MRI Assessment of Cerebral
Blood Flow & Macrophage Accumulation in Mouse Models for
Traumatic Brain Injury |
Lesley May
Foley, B.Sc. |
| 07:30 |
Translation of Traumatic
Brain Injury into Human & Clinical Practice |
Susan Durham,
M.D. |
| 08:00 |
Adjournment |
|
| |
|
|
| Wednesday |
Polycystic Kidney Disease
|
|
| |
Moderators: Diana M. Gomez-Hassan, M.D., Ph.D.,
and Afonso C. Silva, Ph.D. |
| 07:00 |
Mouse Models for Polycystic
Kidney Disease |
Ralph Witzgall, Ph.D. |
| 07:30 |
Polycystic Kidney Disease
and MRI |
Arlene B.
Chapman, M.D. |
| 08:00 |
Adjournment |
|
| |
|
|
| Thursday
|
Oncology Imaging
|
|
| |
Moderators: Pia C.
Maly Sundgren, M.D., Ph.D., and Afonso C. Silva, Ph.D. |
| 07:00 |
Multimodality Radionuclide,
Fluorescence, Bioluminescence Small-Animal Imaging Including
Animal Models for DCE-MRI & DWI MRI
- not
available |
Jinha M. Park,
M.D., Ph.D. |
| 07:30 |
Multimodality In-Vivo
Molecular & Advanced Oncologic Imaging: Human
Metrics/Applications Where is the Animal Model Validation? |
Meng Law,
M.D.,M.B.B.S., F.R.A.C.R. |
| 08:00 |
Adjournment |
|
| |
|
|
| Friday
|
Multiple Sclerosis |
|
| |
Moderators:
Diana M. Gomez-Hassan, M.D., Ph.D., and Afonso C. Silva,
Ph.D. |
| 07:00 |
MRI Tracking of Stem Cells
in Multiple Sclerosis |
Vincent Dousset,
M.D. |
| 07:30 |
Connectivity in MS
|
Tarek Yousry,
M.D. |
| 08:00 |
Adjournment |
|
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