| Sunrise Course:
|
| Modeling & Quantitative Analysis for Body DCE MRI |
| Organizers: Henry Rusinek,
Ph.D., and Min-Ying Lydia Su, Ph.D. |
| |
| Skill Level:
Intermediate - Advanced |
| Tuesday - Friday, 4-7 May
2010 |
| 07:00 - 08:00 |
|
|
OVERVIEW |
This four-hour course will provide
in-depth review of modern techniques for developing and clinical
validation of kinetic models for dynamic contrast-enhanced (DCE)
MRI. Speakers are scientists who are actively involved in developing
and analyzing DCE models for functional body imaging. Course
material follows a top-down sequence, from theoretical/abstract view
to practical/clinical issues. Topics include:
-
Principles of modeling & simulations: model analysis and validation,
sensitivity of parameters to noise, reduction of parameters, Monte
Carlo analysis of bias and variability;
-
Tracer kinetics, compartmental/distributed models, differential
equations, convolution equations;
-
Model complexity and feasibility;
-
Measurement challenges: how do we measure arterial input? Inflow
artifacts, population averaged input function. How do we convert MRI
signal to tracer concentration? Linear conversion, direct
conversion, water exchange regimes;
-
Contrast agents available for DCE MRI: molecular size and its
consequence, factors that contribute to relaxivity, gadolinium, iron
oxide, and manganese agents; hyperpolarized tracers;
-
Trade-off between spatial and temporal resolution; and
-
Model/parameter validation studies, reproducibility/repeatability
studies.
-
The goal is to provide researchers with hard-to locate information
on kinetic modeling and model analysis and validation methodology.
|
|
|
|
EDUCATIONAL OBJECTIVES |
Upon completion of this course
participants should be able to:
- Describe various DCE models used
for different organs including kidney, liver, breast, and
prostate;
- Describe analysis methods used
to measure vascularity, permeability, and blood flow;
- Implement Monte Carlo noise
simulation method to predict parameter bias and precision;
- Compare conventional
compartmental kinetic models and distributed models;
- Apply procedures for converting
MRI signal intensity to tracer concentration; and
- Explain current method for
measuring vascular input function and analyzing its impact on
obtained DCE parameters.
|
|
| Tuesday
|
|
|
| |
Moderators:
David L. Buckley, Ph.D., and Douglas C. Noll, Ph.D. |
| 07:00 |
Principles of Modeling &
Simulations |
Steven P.
Sourbron, Ph.D. |
| 07:30 |
Tracer Kinetics
|
Tong San Koh,
Ph.D. |
| 08:00 |
Adjournment |
|
| |
|
|
| Wednesday
|
|
|
| |
Moderators: Steven P. Sourbron, Ph.D. |
| 07:00 |
From Simple to Complex
|
David L.
Buckley, Ph.D. |
| 07:30 |
Renal Filtration Models
|
Louisa Bokacheva,
Ph.D. |
| 08:00 |
Adjournment |
|
| |
|
|
| Thursday
|
|
|
| |
Moderators:
Henry Rusinek, Ph.D. and Min-Ying Lydia Su, Ph.D. |
| 07:00 |
DCE-MRI Measurement
Challenges |
Mary E.
Loveless, M.S. |
| 07:30 |
Contrast Agents
|
Youssef Zaim
Wadghiri, Ph.D. |
| 08:00
|
Adjournment |
|
| |
|
|
| Friday
|
|
|
| |
Moderators:
Henry Rusinek, Ph.D. and Min-Ying Lydia Su, Ph.D. |
| 07:00 |
ROI or Voxel
|
Min-Ying Lydia
Su, Ph.D. |
| 07:30 |
The Future
|
John C.
Waterton, Ph.D. |
| 08:00 |
Adjournment |
|
| |
|
|
|
|
|