| Weekend Educational Course:
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| Molecular & Cellular
Imaging |
| Organizers: Jeffrey W. M.
Bulte, Ph.D., and Anna V. Moore, Ph.D. |
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| Skill Level:
Intermediate - Advanced |
| Sunday, 2 May
2010 |
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OVERVIEW |
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This one-day course is designed for
graduate students, postdoctoral scientists, and physicians
(radiologists) who are either new to this field or wish to be
updated on the current state of the art in molecular and cellular
imaging applications. The first part of the course will describe how
contrast agents can be used to endow cells with MR-visible
properties, and then how this enables tracking of stem cells and
immune cells in various disease models. Different molecular probes
will be described, of which some can provide contrast with other
modalities. We will also cover combining these probes with
therapeutic drugs in targeting of surface receptors, and issues with
translating molecular imaging from small rodents to large animal
models. Finally, the regulatory issues and current pitfalls that
exist with clinical translation will be outlined in detail.
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EDUCATIONAL OBJECTIVES |
Upon completion of this course
participants should be able to:
- Describe the historical
milestones that have lead to the current status of the field;
- Describe several drawbacks for
each class of MR contrast agents;
- Describe pharmacokinetic
profiles of targeted contrast agents;
- Explain pitfalls associated with
the quantification of molecular and cellular targets;
- List clinical MRI cell tracking
trials; and
- Identify the factors that are
important for the safety and clinical approval of molecular
imaging.
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| 08:30 |
History of Molecular Imaging
|
Angelique Louie,
Ph.D. |
| 09:00 |
PFC-Based Cell Tracking -
not available |
Eric T. Ahrens,
Ph.D. |
| 09:30 |
SPIO-Based Cell Tracking
|
Erik M. Shapiro,
Ph.D. |
| 10:00 |
Break |
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10:00 - 10:15 Meet the
Teachers
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| 10:30
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Theragnostic Capsules
- not available |
Dara L.
Kraitchman, V.M.D., Ph.D. |
| 11:00 |
Reporter Genes
|
Keren Ziv, Ph.D. |
| 11:30 |
Multimodal Nanoparticles
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Willem M. Mulder,
Ph.D. |
| 12:00 |
Break |
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12:00 - 12:15 - Meet the
Teachers |
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| 13:30 |
Novel Imaging Techniques
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Peter M. Jakob,
Ph.D. |
| 14:00 |
Quantification Approaches
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Brian K. Rutt,
Ph.D. |
| 14:30 |
Multilabeling of
Differential Targets |
Silvio Aime,
Ph.D. |
| 15:00 |
Break
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15:00 - 15:15 Meet the
Teachers
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| 15:30 |
Challenges in Imaging Large
Species |
Anna V. Moore,
Ph.D. |
| 16:00 |
What Is Needed for Clinical
Approval? |
Adrian D. Nunn,
Ph.D. |
| 16:30 |
Fibrin Imaging: A Clinical
Example |
Peter Caravan,
Ph.D. |
| 17:00 |
Adjournment |
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17:00 - 17:15 - Meet the
Teachers |
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