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WEEKDAY
EDUCATIONAL COURSE |
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Hyperpolarized 13C
MRS |
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ORGANIZERS: Matthew Merritt, Ph.D.
& Daniel M. Spielman, Ph.D. |
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SKILL LEVEL: Basic-Intermediate |
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Tuesday, 8 May 2012 |
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OVERVIEW |
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This two-hour
course will focus on the methodology and application of metabolic
imaging using 13C MRS of hyperpolarized substrates. With the recent
initiation of first clinical trial of hyperpolarized 13C-labeled pyruvate for the diagnosis and evaluation of prostate cancer, 13C MRS of hyperpolarized compounds is rapidly emerging as a unique and
powerful tool for imaging key metabolic pathways in vivo. The
primary goal of this course is to explore both the basic physics and
imaging technology underlying this technology and to examine the
potential applications to imaging cancer, heart disease, and other
pathologies. The second goal is to familiarize attendees with the
requirements needed to initiate their own hyperpolarized 13C
research programs. |
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EDUCATIONAL OBJECTIVES |
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Upon completion
of this course participants should be able to: |
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Describe the basic physics of dynamic nuclear
polarization; |
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Compare the unique challenges presented by in
vitro, small animal and human studies; |
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Identify the most appropriate acquisition and data
processing approaches for particular needs; |
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Define the primary applications of hyperpolarized
pyruvate for imaging cancer and heart disease; and |
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Describe the potential for other hyperpolarized
substrates beyond Pyruvate. |
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AUDIENCE
DESCRIPTION |
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Because
the aim of this course is to introduce current research
possibilities in the emerging and rapidly advancing field of
hyperpolarized 13C, the course will be designed
both for physicists interested in the technology and
clinicians interested in applications. |
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PROGRAM |
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Click on
 to view
the abstract pdf. Click on 
to view the recorded presentation. |
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Moderators:
Matthew Merritt, Ph.D. & Daniel M. Spielman, Ph.D. |
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16:00 |
Physics
of Dynamic Nuclear Polarization
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Jan H. Ardenkjaer-Larsen, Ph.D. |
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16:20 |
Imaging
Methods
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Dirk
Mayer, Ph.D. |
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16:40 |
Differential Requirements for In Vitro, Small Animal
& Human Studies
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Sarah J.
Nelson, Ph.D. |
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17:00 |
Cancer
Imaging with Hyperpolarized 13C
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Ferdia A.
Gallagher, M.D., M.R.C.P., F.R.C.R. |
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17:20 |
Hyperpolarized 13C Imaging of the Heart
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Craig R.
Malloy, M.D. |
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17:40 |
Beyond
Pyruvate: Other Polarizable Substrates
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Mathilde
H. Lerche, Ph.D. |
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18:00
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Adjournment |
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