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WEEKEND
EDUCATIONAL COURSE |
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Molecular &
Cellular Imaging: From the Bench to the Bed |
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ORGANIZERS: Jeff W. M.
Bulte, Ph.D. & Paula J. Foster, Ph.D. |
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SKILL LEVEL: Intermediate |
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Saturday, 5 May 2012 |
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OVERVIEW |
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This one-day
course will begin with a description of how contrast agents can be
used to endow cells with MR-visible properties, and how this enables
tracking of stem cells and immune cells in various disease models.
Different molecular probes will be described, of which some can
provide contrast with other modalities. Some focus will be on
combining these probes with therapeutic drugs in targeting of
surface receptors. We will cover issues in translating molecular
imaging from small rodents to large animal models. Finally, the
regulatory issues and current pitfalls that exist with clinical
translation will be outlined in detail. |
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EDUCATIONAL OBJECTIVES |
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Upon completion
of this course participants should be able to: |
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Describe the historical milestones that have led to
the current status of the field; |
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Compare the advantages and disadvantages for each
class of MR contrast agents; |
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Describe the pharmacokinetic profiles of targeted
contrast agents; |
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Recognize toxicity profiles and how to circumvent
these; |
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Explain how nanoparticles can be engineered in
different ways; |
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Describe the basic physical principles of different
forms of magnetism; and |
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List factors that are important for the safety and
clinical approval of molecular imaging. |
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AUDIENCE
DESCRIPTION |
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This
course is designed for graduate students, postdoctoral
scientists and physicians (radiologists) who are either new
to this field or wish to be updated on the current state of
the art in molecular and cellular imaging applications. |
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PROGRAM |
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Click on
 to view
the abstract pdf. Click on 
to view the recorded presentation. |
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Moderators:
Jeff W. M. Bulte, Ph.D. & Florence Gazeau, Ph.D. |
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08:30 |
Molecular Imaging in 2012
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Claire
Corot, Ph.D. |
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09:00 |
PARACEST Agents
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Enzo Terreno, Ph.D. |
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09:30 |
T1 Agents
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Eva J.
Toth, Ph.D. |
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10:00
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Break -
Meet the Teachers |
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10:30 |
The
Physics & Chemistry of Nanometer-Sized Materials for
Molecular Imaging
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Kevin M.
Bennett, Ph.D. |
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11:00 |
Interactions of USPIO with the Biological Microenvironment
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Florence Gazeau, Ph.D. |
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11:30 |
Engineered Nanoparticles
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Taeghwan Hyeon, Ph.D. |
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12:00 |
Break |
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12:00-12:15 Meet the Teachers |
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13:30 |
Bimodal Nanoparticles
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Samuel C. Grant, Ph.D. |
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14:00 |
Toxicity
of Nanoparticles
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Uwe Himmelreich, Ph.D. |
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14:30 |
Imaging
of Neuroinflammation
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Vincent Dousset, M.D. |
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15:00 |
Break -
Meet the Teachers |
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15:30 |
19F MRI
Cell Tracking
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Ulrich Flögel, Ph.D. |
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16:00 |
Detecting Amyloid-Beta Plaques in Alzheimer's Disease
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Thomas Mueggler, Ph.D. |
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16:30 |
How to
Bring an Agent to the Market
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Shelton
D. Caruthers, Ph.D. |
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17:00 |
Adjournment |
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17:00-17:15 Meet the Teachers |
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