Traditional
Poster Session - Body |
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Tuesday 8 May 2012
Exhibition Hall |
10:00 - 12:00 |
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1266. |
Quantification of Absolute
Fat Mass: A Validation Study Between Chemical-Shift MRI and
Chemical Analysis
Houchun Harry Hu1,2, Yan Li3, Tim
R. Nagy3, Michael I. Goran4, and
Krishna S. Nayak2
1Radiology, Children's Hospital of Los
Angeles, Los Angeles, California, United States, 2Electrical
Engineering, University of Southern California, Los
Angeles, California, United States, 3Nutrition
Sciences, University of Alabama at Birmingham,
Birmingham, Alabama, United States, 4Preventive
Medicine, University of Southern California, Los
Angeles, California, United States
We validated an approach using the proton density fat
fraction (PDFF) metric derived from chemical-shift
water-fat MRI to compute absolute fat mass (in grams).
The approach was validated in 97 freshly excised organ,
muscle, and adipose tissue samples from four pigs
against reference chemical analysis (CA). A strong
agreement between MRI and CA-derived fat mass was
obtained (slope=1.01, intercept=1.99g, r2=0.98,
p<0.01). The mean difference between MRI and CA was
2.17±3.4g. The results suggest that PDFF provides an
accurate means of determining absolute fat mass and can
facilitate quantitative fat MRI comparisons against
traditional body composition techniques in animals and
humans.
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1267. |
In vivo characterization
of dietary effects and drug efficacy on fat accumulation in
liver, abdomen and skeletal muscle
A Pola1, S Tan2, T Y Keong3,
Z Zhou2, S A Sadananthan1, G
Venkatesh3, S Ishino4, Y Nakano4,
M Watanabe4, T Horiguchi4, B Zhu2,
and S Sendhil Velan3
1Singapoe Institute for Clinical Sciences,
A*STAR, Singapore, 2Takeda
Singapore Pte Ltd, Singapore, 3Laboratory
of Molecular Inaging, Singapore Bioimaging Consortium,
Singapore, 4Takeda
Pharmaceutical Company Limited, Japan
Current measurements to evaluate the anti-obesity
effects are focused on the decrease of the body weight
and visceral fat which takes longer time to show the
effect, therefore a biomarker to predict anti-obesity
effects for short term is of interest. In this study, we
investigated the variation in body weight, intra-hepatic
lipid, intra-myocellular lipid and visceral fat, in a
series of studies using calorie restriction and an
anti-obesity drug (Sibutramine) treatment for 4 weeks in
a diet induced obese rat model. Our findings demonstrate
that MRI/MRS can be utilized to evaluate the therapeutic
potential of novel drugs in rodent models of obesity and
diabetes.
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1268. |
Variations in T2* as a
Potential Indicator of Human Brown Adipose Tissue
Houchun Harry Hu1,2, Thomas G. Perkins3,
Jonathan M. Chia3, and Vicente Gilsanz1
1Radiology, Children's Hospital of Los
Angeles, University of Southern California, Los Angeles,
California, United States, 2Electrical
Engineering, University of Southern California, Los
Angeles, California, United States, 3Philips
Healthcare, United States
We utilized chemical-shift water-fat MRI techniques to
measure T2* relaxation times in human adipose tissue. In
oncology patients and healthy volunteers, we have
consistently observed in suspected sites of
interscapular brown adipose tissue (BAT) an evident
decrease in T2* in comparison to subcutaneous white
adipose tissue (WAT). The lower T2* values in BAT can be
attributed to the tissue’s greater vascularization and
mitochondria (iron) content. On anatomical images, fat
pads with seemingly homogeneous fat signals exhibit
rather heterogenous distributions on the co-registered
quantitative T2* maps, supportive of the notion that
small clusters of BAT adipocytes are likely interspersed
amongst WAT.
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1269. |
Preliminary Indication of
Brown Adipose Tissue In Adult Humans Using Fat-Water MRI
Aliya Gifford1,2, Johan Berglund3,
Joel Kullberg3, Theodore F Towse1,
Malcolm J Avison1,4, and E. Brian Welch1,5
1Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States, 2Chemical
and Physical Biology Program, Vanderbilt University,
Nashville, TN, United States,3Department of
Radiology, Uppsala University Hospital, Uppsala, Sweden, 4Department
of Pharmacology, Vanderbilt University, Nashville, TN,
United States, 5Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States
Brown adipose tissue (BAT) is a thermogenic tissue which
recent 18F-FDG PET and CT studies have imaged and
confirmed the presence of in adult humans. Reliable
identification and spatial mapping methods that avoid
radiation exposure and can distinguish BAT from white
adipose tissue (WAT) would provide a powerful tool with
which to study BAT’s influence on body composition. We
hypothesize that BAT may be visualized and quantified in
humans using fat-water MRI (FWMRI). Whole-body 3T FWMRI
scans were performed on two adult male humans, which
revealed tissue with characteristics (location, size and
fat signal fraction) associated with BAT.
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1270. |
Identification of Brown
Adipose Tissue in a Human Infant
Houchun Harry Hu1,2, Jason P. Tovar3,
Zdena Pavlova3, Thomas G. Perkins4,
and Vicente Gilsanz1
1Radiology, Children's Hospital of Los
Angeles, Los Angeles, California, United States, 2Electrical
Engineering, University of Southern California, Los
Angeles, California, United States, 3Pathology,
Children's Hospital of Los Angeles, Los Angeles,
California, United States, 4Philips
Healthcare, Cleveland, Ohio
We report the unique depiction of brown adipose tissue
(BAT) by MRI and CT in a human three month-old infant.
Based on cellular differences between BAT and more
lipid-rich white adipose tissue (WAT), chemical-shift
MRI and CT were both capable of generating distinct and
complementary signal contrasts between the two tissues
and against surrounding anatomy, utilizing T1-weighted
fat-signal fraction in the former and X-ray attenuation
in the latter. Large bilateral supraclavicular BAT
depots (17 ml in total volume) were clearly visualized
by both modalities, and identified tissues were
subsequently confirmed by biopsy and histological
analysis.
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1271. |
Software for fully
automatic quantification of abdominal fat with manual
correction option: evaluation in morbidly obese patients
Gregor Thörmer1, Henriette Helene Bertram1,
Veronika Peter2, Tatjana Schütz2,
Edward Shang2, Matthias Blüher3,
Thomas Kahn1, and Harald Busse1
1Dept. of Diagnostic and Interventional
Radiology, Leipzig University Hospital, Leipzig, Saxony,
Germany, 2Dept.
of Visceral, Transplantation, Thoracic and Vascular
Surgery, Section Bariatric Surgery, Leipzig University
Hospital, Leipzig, Saxony, Germany, 3Dept.
of Endocrinology and Nephrology, Leipzig University
Hospital, Leipzig, Saxony, Germany
The risk of obesity-related diseases can be assessed by
MRI estimates of the abdominal fat distribution.
Computer-assisted techniques can be used for rapid image
segmentation, but any unsupervised analysis is prone to
errors caused by anatomical variations and artifacts, in
particular for advanced stages of obesity. A custom-made
software with a user interface for the rapid inspection
of automatically segmented images was evaluated on the
example of 20 extremely obese patients (mean BMI=44
kg/m2) and compared to manual processing by two
observers. The presented software appears to be
promising for accurate and time-effective fat
quantification and larger segmentation errors can be
easily corrected in the graphical user environment.
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Traditional
Poster Session - Body |
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Body MRI (Hepatobiliary & GI)
Click on
to view
the abstract pdf. Click on
to view
the poster (Not all posters are available for viewing.)
Tuesday 8 May 2012
Exhibition Hall |
10:00 - 12:00 |
|
|
1272. |
Respiratory-triggered
High-b-value Diffusion-weighted Imaging for the Assessment
of Inflammatory Activity in Crohn’s Disease: A Preliminary
Study
Qi Feng1, Jiong Zhu1, Qing Lu1,
He Wang2, Jia Hua1, and Jianrong
Xu1
1Renji Hospital affiliated to Shanghai
Jiaotong University School of Medicine, Shanghai, China,
China, 2Applied
Science Lab, GE Healthcare, Shanghai, China
Diffusion-weighted imaging sequences at high b values
could identify disease-active and disease-inactive
intestinal segments clearly and a b value of 1500
offered the best balance of diagnostic sensitivity and
specificity in this current study.
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1273. |
Quantitative Diffusion
Weighted MRI biomarkers for the evaluation of Crohn's
ileitis
Moti Freiman1, Jeannette M Perez-Rossello1,
Michael J Callahan1, Mark Bittman1,
Robert V Mulkern1, Athos Bousvaros2,
and Simon K Warfield1
1Radiology, Children's Hospital
Boston/Harvard Medical School, Boston, MA, United
States, 2Inflammatory
Bowel Disease Center, Children's Hospital Boston/Harvard
Medical School, Boston, MA, United States
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1274.
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MRI derived small bowel
motility as a marker of Crohn’s disease activity
Alex Menys1, Freddy Odille2,
Shonit Punwani3, Marco Novelli4,
Manuel Rodriguez-Justo4, Steve Halligan3,
David Atkinson3, and Stuart Taylor3
1Centre for Medical Imaging, University
College London, UCLH, London, United Kingdom, 2INSERM
U947, Université de Lorraine, Nancy, France, 3Centre
for Medical Imaging, University College London, 4Department
of Gastrointestinal Pathology, University College London
Hospital
Optimal medical management of Crohn’s disease (CD)
relies on accurate identification of patients with acute
inflammation. Currently a number of anatomical features
seen on MR enterography have been shown to correlate
closely with disease activity. Abnormal intestinal
motility has been described in CD and may also be a
marker for disease activity. We explored quantitatively
the relationship between CD activity and intestinal
motility assessed using MRI (n=23) against a
histopathological standard of reference and validated
anatomical MRI markers of activity. We found significant
relationships between motility and both end points
suggesting motility as a biomarker for inflammatory
activity.
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1275. |
Measuring T1 of
chyme in the ascending colon in health and diarrhoea
predominant Irritable Bowel Syndrome
Caroline L Hoad1, Klara Garsed2,
Luca Marciani2, Eleanor F Cox1,
Carolyn Costigan1, Robin C Spiller2,
and Penelope A Gowland1
1Physics and Astronomy, University of
Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2Nottingham
Digestive Diseases Centre, NIHR Biomedical Research
Unit, Nottingham University Hospitals NHS Trust,
Nottingham, United Kingdom
T1 of
the chyme in the ascending colon (AC) was measured using
an inversion recovery TrueFISP sequence in healthy
volunteers and patients with diarrhoea predominant
irritable bowel syndrome (IBS-D). Data was fitted to
both 1-compartment and 2-compartment T1 models.
IBS-D patients showed a higher mean T1 in
the chyme of their AC than the healthy volunteers for
both the 1-compartment and short component of the
2-compartment model. This difference may have been due
to faster small bowel transit or a reduced rate of fluid
absorption in the AC.
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1276. |
Investigation of the fate
of different fat emulsion meals in the Gastro-intestinal
using MRI and MRS
Mahamoud Omar Hussein 1,
Luca Marciani2, Caroline L. Hoad1,
Mary Stephenson1, Eleanor F Cox1,
Elisa Placidi1, Susan Pritchard1,
Carolyn Costigan1, Henelyta Ribeiro3,
Elisabetta Ciampi3, Pip Rayment3,
Asish Nandi3, Nick Hedges3, Paul
Sanderson3, Harry Peters F Peters4,
Robin C. Spiller2, and Penny A. Gowland1
1The Sir Peter Mansfield Magnetic Resonance
Centre, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom, 2Nottingham
Digestive Diseases Centre and NIHR Biomedical Research
Unit, University of Nottingham, Nottingham, United
Kingdom, 3Colworth
Science Park, Unilever Discover, Sharnbrook, 4Unilever
Discover, Vlaardingen, Netherlands
Improved knowledge of the relationship between the form
of fat in a meal, the way the meal is handled by the
body and the resulting sense of satiety is critical to
understanding why modern processed foods are associated
with increased obesity. This work aims to determine the
effect of emulsion microstructure on the handling of fat
by the GI tract, using model fat emulsion meals with
different droplet sizes, MRI & MRS. Both stable forms of
the emulsions (coarse+LBG & fine+LBG) lead to delayed
gastric emptying due to increased sense of fullness and
increased SBWC due to increased fat.
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1277. |
Longitudinal T2 relaxometry
to monitor repeated cycles of DSS inducing a chronically
relapsing inflammation
Tom Dresselaers1, Christine Breynaert2,
Johan Cremer2, Kristel Van Steen3,
Clementine Perrier2, Severine Vermeire4,
Paul Rutgeerts4, Jan Ceuppens5,
Gert Van Assche4, and Uwe Himmelreich1
1Biomedical NMR Unit / MoSAIC, K.U.Leuven,
Leuven, Leuven, Belgium, 2Division
of gastroenterology, KULeuven, Leuven, Belgium, 3System
and Modeling Unit, Montefiore Institute, Liege, Belgium, 4Department
of Gastroenterology, University Hospital Gasthuisberg, 5Experimental
immunology, K.U.Leuven
Most experimental animal models of inflammatory bowel
diseases (IBD) fail to accurately reflect the
chronically relapsing inflammation underlying the
complications of human Crohn’s disease. This study
investigated whether repeated cycles of dextran sulfate
sodium salt (DSS) adequately reflect the effects of
chronic transmural healing compared to the acute murine
(DSS) colitis model with recovery. The in vivo T2
relaxometry showed significant differences between the
first and second cycle of DSS. This difference was also
evident from histology and macroscopic scoring. T2
relaxometry may therfore be a promising non-invasive
assessment method in IBD. This model also opens
perspectives to study the effects of healing and
fibrosis in Crohn’s disease.
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1278. |
Comparison of small bowel
aperistalsis using glucagon versus hyoscine administered
intravenously or intramuscularly
Johannes M Froehlich1,2, Nicole Graf3,
Constantin von Weymarn1, Christoph A Binkert1,
Klaus Hergan4, and Andreas Gutzeit1,4
1Department of Radiology, Cantonal Hospital,
Winterthur, Switzerland, 2Scientific
Affairs, Guerbet, Zurich, Switzerland, 3Clinical
Trials Center, Center for Clinical Research, University
Hospital, Zurich, Switzerland, 4Department
of Radiology, Paracelsus Medical University, Salzburg,
Austria
Spasmolysis of the small bowel is crucial for
high-quality imaging of the abdomen/pelvis. The aim of
this prospective investigation was to evaluate the
duration and effectiveness of aperistalsis achieved by
glucagon(GLU/1mg) or hyoscine-N-butylbromide(HBB/40mg)
administered intravenously(i.v.), intramuscularly(i.m.),
or combined i.v./i.m.. Six volunteers underwent five
separate MRI-examinations covering 60-90min. Onset of
aperistalsis did not differ statistically in case of i.v.
administration(65/85sec) ending after
21±12.3min/23.3±14min, respectively. In contrast,
spasmolysis of i.m. HBB and glucagon started
significantly later(p=0.001) with
5.2±1.83min/11.6±10.2min. Aperistalsis lasted for
17.7±23.4min/28.2±26.9min with greater inter-individual
differences(p=0.012). The combined scheme provides a
rapid onset(65sec), prolonged effect(31±10.7min) at the
highest degree of aperistalsis.
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1279. |
Towards clinical MRI
measurements of gastric function and emptying for a
standardised liquid nutrient meal: validation of data
acquisition and analysis.
Caroline L Hoad1, Helen Parker2,
Nicola Hudders2, Carolyn Costigan1,
Eleanor F Cox1, Luca Marciani2,
Mark R Fox2, and Penelope A Gowland1
1Physics and Astronomy, University of
Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2Nottingham
Digestive Diseases Centre, NIHR Biomedical Research
Unit, Nottingham University Hospitals NHS Trust,
Nottingham, United Kingdom
This study develops a clinically applicable protocol to
assess gastric function using MRI. A 400ml doped
nutrient meal was ingested by ten healthy volunteers and
their stomachs imaged using an optimised TrueFISP
sequence. Total gastric (TGV) and liquid only volumes
(LGV) were measured by 3 observers using an intensity
based image segmentation algorithm. These volume data
were then fitted to a complex model of gastric emptying
to parameterize the secretion, relaxation and emptying
of the stomach. Coefficients of variance (CV) were
determined for the volumes and found to below 5% for all
volumes greater than 100 ml.
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1280. |
Bowel motility assessment
during free breathing using Continuously Tagged MR imaging
Marije P. van der Paardt1, André M.J.
Sprengers1, Rolf M. Lamerichs1,2,
Aart J. Nederveen1, and Jaap Stoker1
1Department of Radiology, Academic Medical
Center Amsterdam, Amsterdam, Netherlands, 2Philips,
Eindhoven, Netherlands
This study presents bowel motility assessment with
Continuously Tagged MR imaging. This technique employs
conventional MR-tagging, modified for non-periodic
motion, from which spectral information was extracted
when the tag pattern was deformed by tissue motion.
Spectral analysis for different frequencies was
performed. This non-invasive, free breathing and
automated technique detected changes in bowel motility
in a group of ten healthy volunteers after
administration of a spasmolytic agent. Both in lower and
higher frequencies significant decrease in motility was
observed.
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1281. |
Abdominal MR Imaging at
3.0 T: The Combination of Parallel Radiofrequency
Transmission and B1 Shimming Eliminates Patient-to-Patient
Variations in Image Quality
Thomas G. Perkins1,2, Jeremy L. VanTilburg3,
Gwenael Herigault4, Ty Bremer3,
and Shahid M. Hussain1
1University of Nebraska Medical Center,
Omaha, Nebraska, United States, 2Philips
Healthcare, Cleveland, Ohio, United States, 3The
Nebraska Medical Center, Omaha, Nebraska, United States, 4Philips
Healthcare, Best, Netherlands
Parallel radiofrequency transmission (MTX) was recently
introduced to address the standing wave artifacts
present at 3.0 T by providing independent control over
the RF frequency, phase, and amplitude of the transmit
RF coil elements. This study explored how
patient-specific B1 shimming can eliminate the
patient-to-patient variations in the image quality of
abdominal MRI at 3.0 T. 99 patients were evaluated using
the same abdominal imaging protocol (53 without and 46
with MTX). A significant improvement in overall image
quality and decreased patient-to-patient variability
were realized with MTX. MTX will likely increase the
accessibility and utilization of 3.0T for abdominal MRI.
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1282. |
Repeated Shimming During
MR Imaging of the Liver: Necessary Tool or Historic Relic?
Mustafa Rifaat Bashir1, Brian Marshall Dale2,
Rajan Tilak Gupta1, Jeffrey J Horvath1,
Daniel Tobias Boll1, and Elmar Max Merkle1
1Radiology, Duke University Medical Center,
Durham, NC, United States, 2Siemens
Medical Solutions, Cary, NC, United States
In MRI of the liver, prescan adjustments are often
performed prior to running each pulse sequence. However,
repeating adjustments lengthens scan time, and
adjustment data can, in many cases, be carried forward
from pulse sequence to pulse sequence. Minimizing
prescan adjustments (especially repeated shimming) by
fixing table position and allowing maximal adjustment
tolerances can reduce total examination time without
reducing image quality or the quality of quantitative
MRI data.
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1283. |
Abdominal MRI at 3.0T:
Parallel Radiofrequency Transmission (MTX) Improves the
Signal-to-Noise and Contrast-to-Noise Ratios and Body-habitus-dependent
B1 Inhomogeneity
Mariah Smith-Miloff1, Thomas G. Perkins1,2,
Baojiang Chen3, Jeremy L. Van Tilburg4,
John L. Gollan5, and Shahid M. Hussain1
1Radiology, University of Nebraska Medical
Center, Omaha, Nebraska, United States, 2Philips
Healthcare, Cleveland, Ohio, United States, 3Biostatistics,
University of Nebraska Medical Center, Omaha, Nebraska,
United States, 4The
Nebraska Medical Center, Omaha, Nebraska, United States, 5University
of Nebraska Medical Center, Omaha, Nebraska, United
States
The goal of this study, consisting of 207 patients, was
to quantify the improvements that can be gained at 3.0T
abdominal MRI with the application of parallel
radiofrequency transmission (MTX) primarily by
correcting standing wave artifacts, and whether the
impact of MTX correlates with body habitus. Significant
improvements in mean signal-to-noise and
contrast-to-noise ratios in left liver were observed
with the application of MTX at two separate anatomical
locations. These improvements in SNR and CNR were also
demonstrated to increase as the cross-sectional body
area increased using analysis of variance and linear
regression model analysis.
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1284. |
Age related perfusion and
vascular permeability characteristics of liver measured by
DCE-MRI
David H Gultekin1, Nancy E Kemeny2,
Lawrence H Schwartz3, Mithat Gonen4,
Michael I D'Angelica5, Peter J Allen5,
Yuman Fong5, Leslie H Blumgart5,
Ronald P DeMatteo5, and William R Jarnagin5
1Radiology, Memorial Sloan-Kettering Cancer
Center, New York, NY, United States, 2Medicine,
Memorial Sloan-Kettering Cancer Center, New York, NY,
United States,3Radiology, Columbia
University, New York, NY, United States, 4Epidemiology-Biostatistics,
Memorial Sloan-Kettering Cancer Center, New York, NY,
United States, 5Surgery,
Memorial Sloan-Kettering Cancer Center, New York, NY,
United States
Age related changes in perfusion and vascular
permeability characteristics of the liver tissue have
been investigated using dynamic contrast enhanced
magnetic resonance imaging (DCE-MRI). Correlation
statistics are performed between the age and several DCE-MRI
parameters for subsets of gender and type for a group of
primary liver cancer patients.
|
1285. |
Prediction of
histopathologic grade of hepatocellular carcinoma using
current MRI sequences
Chansik An1, Mi-Suk Park1,
Myeong-Jin Kim1, Yeo-Eun Kim1,
Woo-Suk Chung1, Hyae Min Jeon2,
and Ki-Whang Kim1
1Diagnostic radiology, Yonsei University
Health System, Seoul, Korea, 2Pathology,
Yonsei University Health System, Seoul, Korea
The combination of signal intensities on
diffusion-weighted imaging (DWI) and dynamic subtraction
imaging shows a linear association with histopathologic
grade of hepatocellular carcinoma (HCC). The more the
positive findings shown by an HCC lesion (arterial
enhancement on subtraction imaging and restricted
diffusion on DWI), the higher the grade (p < .001). In
predicting well-differentiated HCC, the positive
predictive value is higher when the findings on DWI and
subtraction imaging are considered together (100%, when
a lesion shows no arterial enhancement and no restricted
diffusion) than when they are considered separately
(81%, no arterial enhancement; 74%, no restricted
diffusion).
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1286. |
Prospective Comparison of
Gadoxetate MRI and Contrast Enhanced CT for the Diagnosis of
Equivocal Lesions Seen on CT - Preliminary Results
Thomas A Hope1, Rizwan Aslam2,
Carlos U Corvera3, Alex Monto4,
Judy Yee2, and Benjamin M Yeh2
1Radiology and Biomedical Imaging, UCSF, San
Francisco, CA, United States, 2Radiology,
SFVA, San Francisco, CA, United States, 3Surgery,
UCSF, San Francisco, CA, United States, 4Gastroenterology,
UCSF, San Francisco, CA, United States
We prospectively studied the utility of gadoxetate for
the further evaluation of equivocal lesions on CT in
patients with cirrhosis. We enrolled 25 patients who had
indeterminate lesions on CT. These patients subsequently
underwent liver MRI using gadoxetate within two weeks of
the CT examination. 32 lesions in 25 patients were
imaged. After the administration of Eovist, 13 lesions
were downgraded, 11 lesions were upgraded and 8 lesions
retained the same grade. In this interim report,
gadoxetate appears to aid in the evaluation of
indeterminate lesions. Additional follow-up needs to be
performed, and goal enrollment is 50 patients.
|
1287. |
Fast T1 mapping for liver
function estimation using Gd-EOB-DTPA
Tetsuya Wakayama1, Keizo Miyakoshi2,
Daisuke Nishiyama2, Masahiro Okada3,
Hiroyuki Kabasawa1, Tatsuro Uto2,
and Takamichi Murakami3
1Global Applied Science Laboratory, GE
Healthcare, Hino, Tokyo, Japan, 2Department
of Radiological Technology, Kinki University Hospital,
Japan, 3Department
of Radiology, Kinki University Faculty of Medicine,
Japan
A novel approach to three dimensionally measure T1 value
of liver with IR-based multiple breath-holding
acquisitions was developed and demonstrated in this
study. The phantom validation revealed that 3D T1map
developed here could provide acceptable accuracy of T1
with larger volume coverage and less scan time, compared
with 2D T1map acquired by conventional 2D IR-FSE. In
volunteer examination, 3D T1map was successfully
obtained from liver. This approach can be expected to
three dimensionally evaluate T1 of the liver with
clinically acceptable scan time.
|
1288. |
T2-weighted VISTA of the
Liver: Parameter Optimization and Its Clinical Application
in Gadoxetate-enhanced MR Imaging
Kengo Yoshimitsu1, Kimiyo Inoue2,
Wirana Angthong2, Ritsuko Fujimtsu2,
Mikiko Shimakura2, Atsushi Takemura3,
Makoto Obara3, and Marc van Cauteren3
1Radiology, Fukuoka University, Fukuoka,
Fukuoka, Japan, 2Fukuoka
University, Japan, 3Philips
Medical Systems, Japan
T2-weighted VISTA for liver imaging was optimized with
RFA 30, TSE factor 100, and radial order turbo
direction. In clinical situation, VISTA with these
parameters and respiratory navigation provided better
T2-weighted images with high resolution and black blood
as compared to breath-hold 2DTSE in gadoxetate-enhanced
MR protocol, without extending the whole examination
time. Because of its susceptibility to motion, however,
signal reduction may occur in ascitic fluid or pleural
effusion, and therefore concurrent use of TSE may be
recommended.
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1289. |
Liver MR T1rho measurement
in liver cirrhosis patients: a preliminary study with a 2D
fast field echo sequence at 3T
Yi-Xiang Wang1, Feng Zhao1,
Vincent Wai Sun Wong2, Jing Yuan1,
Kin Ming Kwong1, and Henry Lik Yuen Chan2
1Dept Imaging & Interventional Radiology, The
Chinese University of Hong Kong, Shatin, NT, Hong Kong, 2Dept
Medicine and Therapeutics, The Chinese University of
Hong Kong, Shatin, NT, Hong Kong
We carried out liver T1rho MR imaging in 10 patients
with liver cirrhosis. T1rho value inhomogeneity was
noted in the liver of the patients, with T1rho value of
right robe tended to be higher than that of left robe.
To quantify liver T1rho value, ROIs were manually placed
on right robe parenchyma region of each slice’s T1rho
maps, excluding observable artifacts and blood vessels.
Nine patients completed the study. With T1rho value
measured from the right liver lobes, the mean value (±
SD) was 51.1±8.1 millisecond, higher than the reported
T1rho mean value of 43.0±2.2 millisecond in healthy
volunteers.
|
1290. |
Mapping of liver function
in thioacetamide-induced rat acute liver injury using an
empirical mathematical model and dynamic contrast-enhanced
MRI with Gd-EOB-DTPA
Shigeyoshi Saito1, Yuki Moriyama1,
Shuichiro Kobayashi1, Ryota Ogihara1,
Daichi Koto1, Akihiko Kitamura1,
Taro Matsushita1, Motoko Nishiura1,
and Kenya Murase1
1Department of Medical Physics and
Engineering, Osaka University, Suita, Osaka, Japan
Our purpose of this study was to evaluate thioacetamide
(TAA)-induced acute liver injury in rats using an
empirical mathematical model (EMM) and dynamic
contrast-enhanced magnetic resonance imaging (DCE-MRI)
with gadolinium ethoxybenzyl diethylenetriamine
pentaacetic acid (Gd-EOB-DTPA). DCE-MRI studies were
performed using Gd-EOB-DTPA, 48 hours after TAA or
saline injection. We calculated the rate of contrast
uptake, the rate of contrast washout, the elimination
half-life of relative enhancement (RE), the maximum RE,
and the time to (REmax) (Tmax) from time-signal
intensity curves using EMM. The EMM is useful for the
assessment of TAA-induced rat acute liver injury using
DCE-MRI with Gd-EOB-DTPA.
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1291. |
Magnetic Resonance Imaging
of HCC: Predictive Findings of Post-transplant Tumor
Recurrence in a Screening Population
Bobby Kalb1, David Becker-Weidman2,
Surya Chundru1, James Costello1,
Puneet Sharma1, Khalil Salman1,
Hina Arif1, and Diego R Martin1
1Radiology, University of Arizona, College of
Medicine, Tucson, AZ, United States, 2Radiology,
Emory University Department of Medicine, Atlanta, GA,
United States
Reduction of post-transplant recurrence of
hepatocellular carcinoma (HCC) is optimized by strict
pre-transplant tumor staging (Milan criteria); however
post-transplant tumor recurrence still occurs in up to
10% of patients with optimal preoperative staging.
Imaging methodologies that are better able to predict
recurrence risk of HCC from pretransplant imaging would
be valuable in the triage of donor organs. Our study
investigates potential imaging features on MRI that may
provide added prognostic information regarding the
biological behaviour of HCC, with the aim to better
predict posttransplant recurrence.
|
1292. |
MRI Approaches for
Determination of Liver Iron Content – a Comparison
Arthur Wunderlich1, Holger Cario2,
and Markus Juchems1
1Diagnostic and Interventional Radiology,
Univ.-Clinic Ulm, Ulm, Baden-Württemberg, Germany, 2Childrens
Hospital, Univ.-Clinic Ulm, Ulm, Baden-Württemberg,
Germany
To compare liver iron content (LIC) determined by
different established MRI methods, we investigated 198
patients with protocols according to published methods,
three using gradient echo (GRE) sequences and one
working with spin echo (SE). The methods correlate
moderately with r=0.90. Weakpoints are the bad
performance of one GRE method near its upper limit and
sensitivity to liver steatosis of the GRE method
addressing high LIC. The latter is most likely the cause
for reduced correlation of SE vs. GRE for high LICs.
Although GRE generally tends to overestimate LIC, both
methods are suitable for decisions concerning patient
management.
|
1293. |
Liver Iron Content
determined with minimal MR scan time
Arthur Wunderlich1, Holger Cario2,
and Markus Juchems1
1Diagnostic and Interventional Radiology,
Univ.-Clinic Ulm, Ulm, Baden-Württemberg, Germany, 2Childrens
Hospital, Univ.-Clinic Ulm, Ulm, Baden-Württemberg,
Germany
To establish an MR method for determining liver iron
content (LIC), we investigated 173 patients with
protocols according to three published methods, two
using gradient echo (GRE) sequences and one working with
spin echo (SE). The latter served as reference. Since
deviations between calculated LIC values occurred, we
performed multiple linear regressions on signal
intensity values of different GRE protocols to get an
improved relation. We showed that in our patients for
LIC values up to 300 µmol/g a single GRE measurement
gives results with good correlation to values determined
with SE. For higher LIC, more GRE protocols are needed.
|
1294. |
T1rho MR imaging for rat
liver with carbon tetrachloride intoxication: a time course
study
Feng Zhao1, Min Deng1, Jing Yuan1,
Queenie Chan2, Jun Yu3, and
Yi-Xiang Wang1
1Department of Imaging and Interventional
Radiology, The Chinese University of Hong Kong, Shatin,
N.T., Hong Kong, 2Philips
Healthcare, Hong Kong, 3Department
of Medicine and therapeutics, The Chinese University of
Hong Kong, Shatin, N.T., Hong Kong
Liver T1rho relaxation became prolonged after bile duct
ligation-induced liver injury in rats has been reported.
In this study, the liver of male Sprague-Dawley rats
treated with carbon tetrachloride (CCl4) were scanned by
T1rho and T2 weighted imaging at baseline, 2 days, 2
weeks, 4 weeks, 6 weeks post CCl4 injection. Liver T1¦Ñ
value increased slightly on day 2, increased further
during the following weeks and was the highest at week 6
post insults. Relative liver signal intensity change on
T2 weighted images followed a different time course.
|
1295. |
Quantification of Hepatic
Macrosteatosis in Living, Related Liver Donors: Comparison
of the Accuracy of Breath-hold MR Imaging Techniques
Jeong Min Lee1, In Pyung Hwang2,
Joon Koo Han2, Berthold Kiefer3,
Andre de Oliverira3, Mun Young Paek3,
and Byung Ihn Choi2
1Radiology, Seoul National University
Hospital, Seoul, Seoul, Korea, 2Seoul
National University Hospital, 3Siemens
Healthcare
Combined use of the T2*-corrected CSI and BH 1H-MRS
allowed a rapid and noninvasive diagnosis of HS in
potential living liver donors; it can also help to avoid
unnecessary biopsies in these patients.
|
1296. |
Resemblance of 1H
MRS Pattern of Bile to that of Serum may Indicate
Alterations in Tight Junctions in Hepatocytes
Tedros Bezabeh1, Omkar B Ijare1,
Nils Albiin2, Annika Bergquist3,
Urban Arnelo4, Matthias Löhr3, and
Ian CP Smith1
1MR Research and Development, National
Research Council Institute for Biodiagnostics, Winnipeg,
MB, Canada, 2Medical
Imaging and Technology, Karolinska Institutet,
Stockholm, Sweden, 3Gastroenterology
and Hepatology, Karolinska Institutet, Stockholm,
Sweden, 4Surgery,
Karolinska Institutet, Stockholm, Sweden
Tight junctions (TJs) are associated with hepatocytes
and cholangiocytes. Specifically, TJs associated with
hepatocytes are concentrated around bile canaliculi, and
serve as barrier to keep bile in bile canaliculi away
from blood-circulation. Alterations in TJs have been
observed in various chronic cholestatic diseases,
resulting in increased paracellular permeability leading
to regurgitation of bile from biliary tract. In this
study, we have observed that 1H
MRS pattern of bile from a few cholestatic patients
resembled to that of serum. We hypothesize that this
anomaly could be due to alterations in TJs and
regurgitation of blood constituents into bile.
|
1297. |
The Physiologic
accumulation of Bile in the Gall Bladder: Evaluation by
Means of Dynamic Contrast-Enhanced MR Cholangiography with
Gd-EOB-DTPA
Tsutomu Tamada1, Akihiko Kanki1,
Tomohiro Sato1, Atsushi Higaki1,
Yasufumi Noda1, Akira Yamamoto1,
Hiroki Higashi1, and Katsuyoshi Ito1
1Radiology, Kawasaki Medical School,
Kurashiki City, Okayama, Japan
We evaluated the physiological accumulation of bile in
gallbladder using DCE-MRC obtained with Gd-EOB-DTPA. As
the results, Twenty-seven of 75 patients (36%) were
delayed type (Visualization of Gd-EOB-DTPA in the end of
the common bile duct is earlier than that of
gallbladder), and remaining 48 (64%) were orthodromic
type (Visualization of Gd-EOB-DTPA in the gallbladder is
earlier than that of end of the common bile duct). The
delay of the bile accumulation in the gallbladder is
associated with T1 hyperintense bile or sludge of
gallbladder, indicating the increase of viscosity and
pressure in the gallbladder.
|
1298. |
The usefulness of
diffusion-weighted imaging (DWI) and apparent diffusion
coefficient (ADC) value for the diagnosis and the assessment
of the therapeutic effect on autoimmune pancreatitis (AIP)
Keizo Tanitame1, Yuko Nakamura1,
Yoko Kaichi1, Chihiro Tani1,
Yukiko Honda1, Miyuki Takasu1, and
Kazuo Awai1
1Diagnostic Radiology, Graduate School of
Biomedical Sciences, Hiroshima University, Hiroshima,
Hiroshima, Japan
Problem To
compare the ADC values of AIP and pancreatic carcinoma
and investigate their usefulness in IgG4-related AIP
during steroid therapy. Methods ADC
values were compared among 10 patients with IgG4-related
AIP, 7 with IgG4-negative AIP, 27 with carcinoma. In 6
patients with IgG4-related AIP ADC values were followed
during steroid therapy. Results The
ADC values were significantly lower in IgG4-related and
-negative AIP than carcinoma (p<0.01, each). ADC values
increased during the therapy in all patients with
IgG4-related AIP. Conclusion ADC
value was useful for differentiating between AIP and
pancreatic carcinoma and for assessing the effects of
steroid therapy.
|
1299. |
The use of non-invasive
MRI to quantify the effect of secretin on pancreatic blood
flow and perfusion in healthy volunteers
Eleanor F Cox1, Janet K Smith2,
John Simpson2, and Susan T Francis1
1SPMMRC, School of Physics & Astronomy,
University of Nottingham, Nottingham, Nottinghamshire,
United Kingdom, 2Nottingham
Digestive Diseases Centre BRU, University of Nottingham,
Nottingham, Nottinghamshire, United Kingdom
Alterations in pancreatic blood flow have been
implicated in pancreatic inflammation and pain. However,
there are few methods to assess pancreatic blood flow
and these are generally invasive, using ionising
radiation or intravenous contrast media, limiting repeat
measures. Here, we use secretin stimulation to alter
blood flow. We repeatedly measure pancreatic tissue
perfusion using respiratory-triggered arterial spin
labelling, and vessel blood flow (superior mesenteric
SMA, gastroduodenal GDA, hepatic, splenic arteries),
using phase contrast MRI, before and at 10 minute
intervals following secretin administration. We show
pancreatic tissue perfusion, SMA flow, and GDA flow,
were all significantly increased following secretin
administration.
|
1300. |
ALTERATION IN SECRETORY
FLOW OF PANCREATIC JUICE IN PATIENTS WITH INTRADUCTAL
PAPILLARY MUCINOUS NEOPLASMS OF THE PANCREAS: EVALUATION BY
MEANS OF SERIAL MRCP WITH SPATIALLY LABELED INVERSION
RECOVERY PULSE
Kazuya Yasokawa1, Katsuyoshi Ito1,
Tsutomu Tamada1, Teruyuki Torigoe1,
Akihiko Kanki1, Yasufumi Noda1,
and Koji Yoshida2
1Radiology, Kawasaki Medical School,
Kurashiki, Okayama, Japan, 2Kawasaki
Medical School, Kurashiki, Okayama, Japan
This study evaluated non-invasively the alteration in
the secretory flow of pancreatic juice in patients with
IPMNs of the pancreas by using cine dynamic MRCP with
spatially labeled IR pulse in comparison with the
physiological flow of pancreatic juice in normal
subjects. The flow of the pancreatic juice was impaired
or became slow in patients with IPMNs, probably due to
mixture of mucinous component from IPMNs in the
pancreatic duct. It would be important to be aware of
the alteration in the secretory flow of the pancreatic
juice in patients with IPMNs even though pancreatic
exocrine function is normal.
|
1301. |
Pancreatic and Hepatic Fat
Measurements using 1H MRS and mDIXON with Flexible Echo
Times.
Roshan Livingstone1, Paul Begovatz1,
Sabine Link1, Bettina Nowotny1,
Birgit Klueppelholz2, Guido Giani2,
Juergen Bunke3, Michael Roden1,4,
and Jong-Hee Hwang1
1Institute of Clinical Diabetology, German
Diabetes Center, Düsseldorf, Germany, 2Institute
for Biometry and Epidemiology, German Diabetes Center,
Düsseldorf, Germany,3Philips Healthcare,
Hamburg, Germany, 4Department
of Metabolic Diseases, University Clinics, Heinrich
Heine University, Düsseldorf, Germany
1H-MRS is considered the gold standard for liver fat
measurements, however, it is unclear whether H-1 MRS is
more accurate for the pancreas than DIXON methods. A
flexible 2-point mDIXON method (TE1/TE2 = 1.12/2.0 ms)
was compared to 1H-MRS for fat fraction of the liver and
pancreas in 19 volunteers. Values of hepatic fat
fraction by mDIXON and 1H-MRS correlated well with each
other (r = 0.96, p<0.00001), however, in the pancreas a
correlation of (r=0.66, p<0.001) was found, which was
probably attributed to differences in the amount and
distribution of fat between the two organs.
|
1302. |
Effect of Weight Loss on 1H
MR-observed Muscle, Liver and Abdominal Fat Distribution and
Insulin Sensitivity
Suresh Anand Sadananthan1,2, Eric Khoo Yin
Hao3, Melvin K-S Leow1,4, ChinMeng
Khoo3, Lee Yung Seng1,5, Peter
Gluckman1, Tai E Shyong1,3, and S.
Sendhil Velan1,6
1Singapore Institute for Clinical Sciences,
A*STAR, Singapore, 2Dept.
of Obstetrics & Gynaecology, National University of
Singapore, Singapore, 3Dept.
of Medicine, National University of Singapore, 4Dept.
of Endocrinology, Tan Tock Seng Hospital, Singapore, 5Dept.
of Pediatrics, National University of Singapore, 6Singapore
Bioimaging Consortium, A*STAR, Singapore
MRI and MRS allow for the investigation of changes in
fat metabolism by exercise/dietary intervention in
liver, muscle and abdominal fat (subcutaneous (SAT) and
visceral (VAT)). In this study, we investigated the
changes in fat distribution pre- and post-weight loss
intervention in overweight Chinese men. The 16-week
weight loss program consisted of three 90-min exercise
sessions per week and a diet comprising of a caloric
deficit of upto 1000 kcal. The results showed
significant gain in fat depots post-weight loss except
for IMCL. Further, the increase in SAT, VAT and
%body-fat revealed significant correlations with the
increase in insulin sensitivity.
|
1303. |
Introduction and
Evaluation of Different Approaches for the
(Semi-)quantitative Assessment of Renal Sodium Content with
23Na MR Imaging
Stefan Haneder1, Simon Konstandin2,
John Morelli3, Lothar R Schad2,
Stefan O Schoenberg1, and Henrik J Michaely1
1Institute of Clinical Radiology and Nuclear
Medicine, University Medical Center Mannheim, Mannheim,
Baden-Württemberg, Germany, 2Computer
Assisted Clinical Medicine, Heidelberg University,
Mannheim, Baden-Württemberg, Germany, 3Scott
and White Memorial Hospital and Clinic – Texas A&M
University Health Sciences Center, Temple, Texas, United
States
Two new approaches are introduced and evaluated for the
(semi-)quantitative assessment of the renal sodium
content with 23Na MR imaging before and after a water
load. One approach used the cerebrospinal fluid as
internal reference for the cortico-medullary 23Na
gradient. The second approach quantified the
cortico-medullary 23Na gradient with reduced numbers of
slices. Both methods are compared to the gold standard –
quantification with complete data sets and external
references. Both approaches showed non-significant
differences compared to the gold standard and seem to be
a feasible and faster alternative for potential clinical
application.
|
1304. |
T2 Relaxation
Assessments of Kidney and Liver Disease in the PCK Rat Model
of Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Huaiqiang Sun1,2, Lan Lu2, David L
Wilson1, Katherine M Dell3,4, and
Chris A Flask1,2
1Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States, 2Radiology,
Case Western Reserve University, Cleveland, OH, United
States,3Pediatrics, Case Western Reserve
University, and Rainbow Babies and Children’s Hospital,
Cleveland, OH, United States, 4CWRU
Center for the Study of Kidney Disease and Biology, Case
Western Reserve University, Cleveland, OH, United States
Autosomal Recessive Polycystic Kidney Disease (ARPKD) is
a multiorgan disease manifest as increasing renal cysts
as well as hepatobiliary dilatation and congenital
hepatic fibrosis. We are exploring the potential of T2 relaxation
assessments to assess renal cystic burden and
hepatobiliary dilatation in the PCK rat model of ARPKD.
In this study, we demonstrated that removal of early
echoes (TE = 10-30ms) from the T2 calculation
can reduce the biexponential nature of the T2 decay
curve likely caused by tissue perfusion. As a result,
these T2 estimations
may provide accurate estimates of hepatobiliary
dilatation as well as renal cystic burden.
|
1305. |
MR Elastography (MRE):
Evaluation of New Inversion Algorithm and Quantitative
Analysis Method
Alvin C Silva1, Annelise M Silva2,
Roger C Grimm3, Kevin J Glaser3,
Amy K Hara1, and Richard L Ehman3
1Radiology, Mayo Clinic Arizona, Scottsdale,
Arizona, United States, 2Xavier,
Scottsdale, Arizona, United States, 3Radiology,
Mayo Clinic Rochester, Rochester, Minnesota, United
States
MR Elastography is a promising, noninvasive technique
for discriminating normal from diseased liver, including
fibrosis stage. With the introduction of a new inversion
algorithm (MMDI) and confidence mask, suggested
published threshold values in this regard may have to be
modified. The purpose of this study is to compare
calculated mean shear hepatic stiffness calculations (kPa)
between the two inversions algorithms and assess inter-
& intraobserver variability between two measurement
techniques (ie, confidence threshold mask versus
free-hand ROI).
|
1306. |
Novel MR Fine Texture
Spectroscopy Technique Enabling Visualization of Fine
Structures: Fibrosis detection in chronic Liver Disease
Surya Chundru1, Diego Martin1,
Puneet Sharma1, Ryan Pathak2,
Amanda Cox2, Lance W Farr2, Tim
James2, and Peter Jezzard3
1University Medical Center, University of
Arizona, Tucson, Arizona, United States, 2Acuitas
Medical, Swansea, United Kingdom, 3Department
of Clinical Neurology, University of Oxford, Oxford
Non-invasive measurement of liver fibrosis in chronic
liver disease (CLD) remains an unmet clinical need. We
have developed a Fine Texture Analysis technique
(wavelength analysis of fine texture wavelengths below
the resolution limit of clinical MRI) and applied this
technique to specially acquired MR data to evaluate the
capacity for detecting liver fibrosis (LF). LF should
alter the normal background liver texture to produce
gradient stages of signature wavelength distributions as
the coarser fibrotic texture replaces the finer vascular
normal texture. Our results show good correlation
between clinical assessment of disease stage and
spectral features, supporting our hypothesis.
|
|
|
Traditional
Poster Session - Body |
|
Click on
to view
the abstract pdf. Click on
to view
the poster (Not all posters are available for viewing.)
Tuesday 8 May 2012
Exhibition Hall |
10:00 - 12:00 |
|
|
1307. |
Measuring the changes in
renal blood flow due to unbalanced and balanced crystalloid
infusions
Eleanor F Cox1, Abeed H Chowdhury2,
Dileep N Lobo2, and Susan T Francis1
1SPMMRC, School of Physics & Astronomy,
University of Nottingham, Nottingham, Nottinghamshire,
United Kingdom, 2Nottingham
Digestive Diseases Centre BRU, University of Nottingham,
Nottingham, Nottinghamshire, United Kingdom
Infusions of large volumes of saline (an unbalanced
crystalloid) can cause hyperchloremic acidosis, which
has previously been shown to reduce renal blood flow in
canine models. We predicted that a balanced crystalloid
with an electrolyte composition closer to human blood
plasma would not produce this effect on renal blood flow
and perfusion. Following 2 litre infusions over 60
minutes in 12 healthy males, the renal artery blood flow
velocity and renal cortical perfusion were significantly
reduced following the unbalanced crystalloid, whilst no
significant change in flow or perfusion were found for
the balanced crystalloid.
|
1308. |
Evaluation of renal
oxygenation in patients with renal disease using 3.0T BOLD
MRI
Sung Il Hwang1, Hak Jong Lee2, and
Ho Jun Chin2
1Seoul National University Bundang Hospital,
Seongnam, Gyeonggi-do, Korea, 2Seoul
National University Bundang Hospital
Renal BOLD MRI can be efficiently performed with 3.0 T
MRI in patients. Renal medullary hypoxia is decreased in
patients with acute renal failure patients.
|
1309. |
Assessment of renal
function after conformal radiotherapy and intensity
modulated radiotherapy by functional 1H-MR-imaging and
23Na-MR-imaging.
Stefan Haneder1, Judit Boda-Heggemann2,
Simon Konstandin3, Lothar R Schad3,
Frederik Wenz2, Frank Lohr2,
Stefan O Schoenberg1, and Henrik J Michaely1
1Institute of Clinical Radiology and Nuclear
Medicine, University Medical Center Mannheim, Mannheim,
Baden-Württemberg, Germany, 2Department
of Radiation Oncology, University Medical Center
Mannheim, Mannheim, Baden-Württemberg, Germany, 3Computer
Assisted Clinical Medicine, Heidelberg University,
Mannheim, Baden-Württemberg, Germany
Conventional 3-dimensional conformal radiotherapy
(3D-CRT) after gastric cancer results in ablative doses
to the cranial part of the left kidney, while
image-guided intensity-modulated radiotherapy (IG-IMRT)
provides improved kidney sparing. Functional magnetic
resonance imaging at 3.0T including BOLD, DWI and
23Na-imaging was used to evaluate renal status after
radiotherapy with 3D-CRT or IG-IMRT. Marked
morphological/functional effects were observed in
high-dose areas (3DCRT) while no alteration in kidney
function was observed in IG-IMRT patients who received
lower doses of radiation. Functional MRI at 3.0T seems
feasible for investigation of post-radiotherapeutic
renal changes.
|
1310. |
Non-contrast enhanced
Human Renal Perfusion Imaging Using Arterial Spin Labeling
at 7T: Initial Experience
Xiufeng Li1, Carl Snyder1,
Pierre-Francois Van de Moortele1, Kamil
Ugurbil1, and Gregory J. Metzger1
1Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States
Arterial spin labeling imaging, as a non-invasive and
non-contrast enhanced approach, is very suitable for
longitudinal evaluation of kidney function after
transplantation, and can significantly benefit patients
with renal dysfunction or other contraindications to the
use of MR contrast-agent. The increased longitudinal
relaxation time of the blood at ultrahigh field (UHF)
can improve non-contrast enhanced perfusion imaging
using ASL. To evaluate the technical challenges and
potential benefits of performing renal ASL perfusion
studies at UHF, the FAIR technique was implemented and
used to study kidney perfusion in normal healthy
controls. In this article, our initial experience and
results are presented.
|
1311. |
AGE-RELATED CHANGE IN
RENAL CORTICOMEDULLARY DIFFERENTIATION: EVALUATION WITH
NON-CONTRAST-ENHANCED STEADY-STATE FREE PRECESSION (SSFP) MR
IMAGING WITH TIME-SPATIAL LABELING INVERSION PULSE
(TIME-SLIP)
Yasufumi Noda1, Akihiko Kanki2,
Tsutomu Tamada2, Akira Yamamoto2,
Atsushi Higaki2, Tomohiro Sato2,
Daigo Tanimoto2, and Katsuyoshi Ito2
1KAWASAKI MEDICAL SCHOOL, KURASHIKI, OKAYAMA,
Japan, 2KAWASAKI
MEDICAL SCHOOL
Age-related change in renal corticomedullary
differentiation was evaluated by means of
non-contrast-enhanced SSFP MR imaging with Time-SLIP. In
normal kidney, non-contrast-enhanced SSFP MR imaging
with Time-SLIP can be used to assess the renal
corticomedullary differentiation and cortical thickness
without influence of the aging although optimal TI value
for the best visualization of renal corticomedullary
junction should be shortened with aging. This fact
suggested that SSFP MR imaging with Time-SLIP has a
potential to evaluate the renal function based on renal
cortical thickness or volume without considering an
age-related change.
|
1312. |
Blood Oxygen
Level-Dependent (BOLD) MRI of Diabetic Nephropathy
Eito Kozawa1, Tsutomu Inoue2,
kaiji Inoue3, Hiromichi Suzuki2,
and Junji Tanaka4
1Diagnosis Imaging, Saitama Medical
University, International Medical Center, Hidaka-shi,
Saitama, Japan, 2Nephrology,
Saitama Medical University, Japan, 3radiology,
Saitama Medical University, Japan, 4Radiology,
Saitama Medical University, Japan
Renal BOLD MRI provides comprehensive information
including changes in intrarenal oxygenation.
|
1313. |
Hemodynamic effects of
furosemide on renal perfusion as evaluated by noninvasive
ASL-MRI
Jing Wang1, Yudong Zhang2,
Xiaoying Wang1,2, Jue Zhang1,3,
and Jing Fang1,3
1Academy for Advanced Interdisciplinary
Studies, Peking University, Beijing, China, 2Department
of Radiology, Peking University First Hospital, Beijing,
China, 3College
of Engineering, Peking University, Beijing, China
In this study, short-term effects of furosemide on renal
perfusion were investigated by using FAIR-ASL at 3T MR.
Baseline and post ASL images were acquired on healthy
subjects before and after furosemide administration to
measure the renal hemodynamic response. Furosemide
produced a remarkable reduction in medullar RBF, while
cortical and global RBF changes did not reach a
significant level. Furosemide administration is
associated with a prominent decrease in the medullar
blood perfusion, but its hemodynamic effects on the
renal cortex still need further study, while ASL-MRI
provides an alternative way to noninvasively monitor
changes in renal function.
|
1314. |
Withdrawn
|
1315. |
Fractal Analysis of
Real-Time BOLD Data from Healthy Kidneys
Marla Shaver1, and Michael Noseworthy2
1School of Biomedical Engineering, McMaster
University, Hamilton, Ontario, Canada, 2School
of Biomedical Engineering, Electrical and Computer
Engineering, McMaster University, Hamilton, Ontario,
Canada
In this study, real-time BOLD data from healthy kidneys
was analyzed to determine whether signal variations are
fractal, and if so whether they can be characterized as
fractional Gaussian noise (fGn) or fractional Brownian
motion (fBm). Images were acquired using a T2* weighted
GRE EPI sequence. Subjects were instructed to breath
quietly during image acquisition. Rapidly acquired BOLD
data from both kidney cortex and medulla behave
fractally, where the majority of the data is
characterized as fGn.
|
1316. |
Comparison of
free-breathing versus navigator-controlled
diffusion-weighted MR imaging of the kidneys: effects on ADC
statistics.
Neil Peter Jerome1, Matthew Orton1,
James d'Arcy1, David J Collins1,
Dow-Mu Koh2, and Martin O Leach1
1CRUK-EPSRC Cancer Imaging Centre, The
Institute of Cancer Research, Sutton, Surrey, United
Kingdom, 2Department
of Radiology, Royal Marsden Hospital, Sutton, Surrey,
United Kingdom
Discussions about the optimum breathing modality for
acquiring abdominal diffusion-weighted MR images include
consideration of navigator-controlled acquisition to
reduce motion blurring, but this is dependent on
repeatability of respiratory cycle and is inevitably
time-inefficient. Adopting a free-breathing strategy
allows greater averaging for the same acquisition time;
we show that fitted pefusion-insensitive ADC parameters
from the kidneys of a volunteer cohort are not
significantly different between navigator-controlled and
free-breathing modalities. Global statistics are
reported, as well as for renal cortex and pyramid ROIs,
and distibutions of ADCs and of signal intensities at
each b-value are shown to be not significantly
different.
|
1317. |
3D BOLD-MRI at high
PAT-factors: How to save time!
Florian Lietzmann1, Frank G. Zoellner1,
Tanja Gaa1, Ulrike I. Attenberger2,
and Lothar R. Schad1
1Computer Assisted Clinical Medicine,
Heidelberg University, Mannheim, Germany, 2University
Medical Centre Mannheim, Institute of Clinical Radiology
and Nuclear Medicine, Mannheim, Germany
In recent years blood oxygen level dependent (BOLD) MRI
has gained more importance in the entire field of
MRI.Therefore we performed a clinical study with 4
healthy volunteers and investigated if the signal
changes in the kidney due to a water intake of the
volunteers could satisfactorily being followed and if
our optimized sequences with high parallel imaging
acceleration factors can be used for quick renal
BOLD-MRI. We investigated three different sequences each
with a different resolution and imaging time. After T2*
mapping in the post processing step and a ROI-readout,
the time courses showed the expected signal changes
after the water intake independent of the used sequence.
|
1318. |
Renal Compartment
Segmentation by Wavelet-based Clustering of 3D DCE-MRI of
Human Kidney
Frank G Zoellner1,2, Sheng Li1,3,
Andreas D Merrem1, Jarle Roervik2,4,
Arvid Lundervold4,5, and Lothar R Schad1
1Computer Assisted Clinical Medicine,
Heidelberg University, Mannheim, Germany, 2Section
for Radiology, Dept. of Surgical Sciences, University of
Bergen, Bergen, Norway,3Institute of
Knowledge Based Engineering, School of Mechanical
Engineering, Shanghai Jiao Tong University, Shanghai,
China, 4Dept.
of Radiology, Haukeland University Hospital, Bergen,
Norway, 5Dept.
of Biomedicine, University of Bergen, Bergen, Norway
Correct determination (segmentation) of the renal
compartments within the images is crucial to obtain i.e.
whole kidney GFR via pharmacokinetic modelling. We
propose a wavelet-based segmentation method to group the
voxel time courses and thereby segment the renal
compartments. This method was applied to DCE-MRI data
sets of 4 healthy volunteers and 3 patients. On average,
the renal cortex could be segmented at 88%, the medulla
at 91%, and the pelvis at 98% accuracy. Time intensity
curves showed well known characteristics of perfusion
time curves for the respective compartments. In
conclusion, wavelet based clustering of DCE-MRI of
kidney is feasible.
|
1319. |
MRI characterization of
renal masses using gadolinium-enhanced subtraction
technique: Accuracy of a quantitative methods to detect
tumor enhancement
Martin P Smith1, Olga Brook1, Long
Ngo2, Neil Rofsky3, and Ivan
Pedrosa4
1Radiology, BIDMC, Boston, MA, United States, 2Medicine,
BIDMC, Boston, MA, United States, 3Radiology,
UT Southwestern, Dallas, MA, United States, 4Radiology,
UT Southwestern, Dallas, TX, United States
Quantitative methods can be used to diagnose accurately
solid enhancing renal tumors with contrast-enhanced MRI
that works with image subtraction and comparing SI
measurements between unenhanced and contrast-enhanced
images.
|
1320. |
Renal Size estimation by
MRI in Living Renal Allograft Donation: Follow-up of the
Remaining and of the Donated Kidney
Peter Vermathen1, Aurelia Rusch-Kölbener1,
Tania Bühler1, Tobias Binser1,
Harriet C Thoeny2, Felix J Frey3,
Chris Boesch1, and Ute Eisenberger3
1Depts Clinical Research and Radiology,
University Bern, Bern, Switzerland, 2DRNN,
Inselspital Bern, Bern, Switzerland, 3Dept.
Nephrology and Hypertension, Inselspital Bern, Bern,
Switzerland
The effect of unilateral nephrectomy on the sizes of the
remaining kidneys was investigated longitudinally over 1
year in 13 living renal donors and the sizes of the
explanted kidneys were followed up in the corresponding
recipients. The remaining kidneys of donors increased
significantly by ~15% early after explantation and
continued to increase slightly until 1 year. Renal sizes
of allografts correlated significantly with those
obtained in the same kidneys before transplantation in
donors. After transplantation the allograft sizes
remained constant. Conclusion: The remaining kidney of
donors exhibits compensatory size growth to overcome
renal mass reduction due to unilateral nephrectomy.
|
1321. |
CORTICOMEDULLARY
DIFFERENTIATION OF THE KIDNEY WITH NON-CONTRAST-ENHANCED MR
IMAGING WITH TIME-SPATIAL LABELING INVERSION PULSE:
COMPARISON OF IMAGING WITH FAST ASYMMETRIC SPIN ECHO AND
STEADY-STATE FREE-PRECESSION SEQUENCES
Akihiko Kanki1, Katsuyoshi Ito1,
Tsutomu Tamada1, Yasufumi Noda1,
Kazuya Yasokawa1, and Tomohiro Sato1
1Radiology, Kawasaki Medical School,
Kurashiki, Okayama, Japan
This study compared the two different MR sequences, fast
asymmetric spin echo (FASE) and steady-state
free-precession (SSFP) combined with time-spatial
labeling inversion pulse (Time-SLIP), for the better
visualization of corticomedullary differentiation in the
normal kidney. Both FASE and SSFP MR imaging with
Time-SLIP can be used to visualize the renal
corticomedullary differentiation in normal kidneys
without using contrast agents. SSFP sequence with
Time-SLIP may be preferable for the measurement of renal
cortical thickness or volume because of good
visualization of corticomedullary junction and high
image quality although FASE sequence with Time-SLIP had
high corticomedullary contrast ratio.
|
1322. |
The investigation of
apparent diffusion coefficient in renal cortex and medulla
during the cardiac cycle.
Masahiro Umeda1, Toshihiro Higuchi2,
Yuki Mori3, Yoshichika Yoshioka4,
Yasuharu Watanabe1, Yuko Kawai1,
Tomokazu Murase2, and Chuzo Tanaka2
1Medical Informatics, Meiji University of
Integrative Medcine, Nanantanshi, Kyoto, Japan, 2Neurosurgery,
Meiji University of Integrative Medcine, Nanantanshi,
Kyoto, Japan,3Immunology Frontier Center,
Osaka University, Suita, Osaka, Japan, 4Immunology
Frontier Research Center, Osaka University, Suita,
Osaka, Japan
The renal ADCs with high b values (100 - 800 s/mm2)
were investigated during the cardiac cycle. The average
ADC of the renal medulla was higher than that of cortex
( P < 0.01). However a maximum renal arterial flow
occurred at 60 ms after R-wave during the cardiac cycle,
the changes of ADC with high b value showed no peak at
the same time . The renal ADC with high b values was
less influenced by renal blood flow.
|
1323. |
Visualization of Renal
Artery and Its Branches of the Middle-aged Healthy Adults:
The Initial Study of Non-Contrast-Enhanced MR Angiography
Using a Time-Spatial Labeling Inversion Pulse
Mengyu Liu1, Huadan Xue2, Xuan
Wang2, Yuan Liu2, and Zhengyu Jin2
1PLA general hospital, Beijing, Beijing,
China, 2Peking
Union Medical College Hospital
26 middle-aged healthy volunteers were enrolled in this
study to receive three-dimensional (3D) non-contrast
enhanced MR angiography with a time-spatial labeling
inversion pulse (Time-SLIP) of renal artery. All
volunteers received coronal orientations with 3
different black blood inversion time(900, 1200, 1500
ms). Relative signal intensity (rSI) of renal artery,
visibility score (Rank 1-4) in 3 segments of the renal
artery and the numbers of the branches were evaluated as
indexes of the Time-SLIP sequence image quality. We get
the conclusion that a black blood inversion time of
1200ms was considered to be the optimal choice for this
purpose.
|
1324. |
The feasibility study of
exploring arterial spin labeling for renal glomerular
filtration rate (GFR) mapping
Jing Wang1, Yudong Zhang2, Yue
Zhang3, Xiaoying Wang1,2, Jue
Zhang1,3, and Jing Fang1,3
1Academy for Advanced Interdisciplinary
Studies, Peking University, Beijing, China, 2Department
of Radiology, Peking University First Hospital, Beijing,
China, 3College
of Engineering, Peking University, Beijing, China
This study developed an approach for renal perfusion and
glomerular filtration rate mapping based on the
combination of pulsed arterial spin labeling technique
and a spin-echo EPI with multiple TEs sequence on
clinical 3T MR. Each of ten healthy young subjects
accepted 12 breath-hold ASL scans for different TEs
acquisition. Based on the proposed method, the RBF,
blood R2* and GFR maps were obtained simultaneously. We
hope that this MR technique can be combined with other
functional methods to provide a complete noninvasive
assessment of renal status in a single examination.
|
1325. |
Timecourse of BOLD
response in normal rat kidney following vasomodulator
administration using standard 1.5T clinical hardware.
Neil Peter Jerome1, Jessica K R Boult1,
Matthew Orton1, James d'Arcy1,
David J Collins1, Dow-Mu Koh2, and
Simon P Robinson1
1CRUK-EPSRC Cancer Imaging Centre, The
Institute of Cancer Research, Sutton, Surrey, United
Kingdom, 2Department
of Radiology, Royal Marsden Hospital, Sutton, Surrey,
United Kingdom
Preclinical studies are increasingly performed on
clinical systems, using superior hardware and conferring
greater clinical relevance. Limitations in signal,
leading to lack of spatial resolution or insufficient
signal for fitting decay curves, can be mitigated by use
of an extremity loop coil with a standard head array for
parallel acquisition. We demonstrate observation of
time-dependent changes in T2* from normal rat
kidney following administration of vasomodulators such
as hydralazine, furosemide, and angiotensin II, and show
the potential of such a set-up to probe homeostatic
response to vasomodulation, with potential for
extrapolation to renal disease and pathophysiological
studies.
|
1326. |
Does a 100% oxygen gas
challenge affect renal blood flow, as measured using
Arterial Spin Labelling?
Katherine Frances Holliday1,2, Geoffrey J M
Parker1,2, Mark Dobbs1,2, and
Josephine Helen Naish1,2
1Imaging Sciences, The University of
Manchester, Manchester Academic Health Science Centre,
Manchester, United Kingdom, 2Biomedical
Imaging Institute, Manchester, United Kingdom
OE-MRI uses an oxygen gas challenge to investigate
tissue oxygenation by measuring a change in signal or T1;
literature suggests this challenge may cause a reduction
in blood flow. This study aimed to investigate the
effect of such a gas challenge on renal blood flow using
ASL. 10 healthy subjects were recruited. Across all
subjects no significant difference was found in blood
flow in the renal cortex. However if we ignore blood T1 changes
there is an apparent significant decrease in flow. It is
therefore important to consider blood T1 changes
when using ASL to measure the effect of oxygen.
|
1327. |
Breath-hold,
respiratory-triggered, and Free-breathing Diffusion-Weighted
MR Imaging of Renal Lesions: Comparison of Imaging Quality
and Apparent Diffusion Coefficient Values
Haiyi Wang1, Huiyi Ye1, Jia Wang1,
Xu Zhang2, Aitao Guo3, Yingwei
Wang1, and Xinkun Wang1
1Department of Radiology, Chinese PLA General
Hospital, Beijing, China, 2Department
of Urology, Chinese PLA General Hospital, Beijing,
China, 3Department
of Pathology, Chinese PLA General Hospital, Beijing,
China
Diffusion-weighted imaging (DWI) has become an
established method for abdominal imaging. The kidney is
a particularly interesting organ to study with DWI.
Conventional DWI requires breath-hold during scanning,
which sometimes cannot be realized for patients with
breath-hold difficulty. This study compares the
respiratory-triggered, free-breathing and breath-hold
DWI of renal lesions, and the conclusion is drawn that
respiratory-triggered and free-breathing DWI can be
appropriate sequences for evaluation of renal lesions
without any compromise in the calculated ADC values, and
free-breathing DWI can display better image quality.
|
1328. |
Renal Artery Anatomy and
Renal Artery Stenosis: Non-Contrast-Enhanced MR Angiography
Using a Time-Spatial Labeling Inversion Pulse Compared With
CTA
Mengyu Liu1, Huadan Xue2, Xuan
Wang2, Min Sheng2, Yuan Liu2,
and Zhengyu Jin2
1PLA general hospital, Beijing, Beijing,
China, 2Peking
Union Medical College Hospital
25 patients were enrolled in this study to evaluate the
renal anatomy and renal stenosis in three-dimensional
(3D) non-contrast enhanced MR angiography with a
time-spatial labeling inversion pulse (Time-SLIP)
compared with computer tomography angiography ( CTA).
All subjects received both coronal and axial views of
MRA with a Time-SLIP. The variants of renal artery were
same and the evaluation of renal artery stenosis were
consistent of the two image modalities. The discrepancy
between them may related to the calcification of the
renal artery and the change of the hemodynamic of the
stenosis.
|
1329. |
DTI in human kidney: Image
co-registration improves signal stability and lowers
variability in diffusion parameter estimation
Peter Vermathen1, Huanxiang Lu2,
Tobias Binser1, Ute Eisenberger3,
Chris Boesch1, and Mauricio Reyes2
1Depts Clinical Research and Radiology,
University Bern, Bern, Switzerland, 2Institute
for Surgical Technology and Biomechanics, University
Bern, Bern, Switzerland, 3Dept.
Nephrology and Hypertension, Inselspital Bern, Bern,
Switzerland
Physiological motion caused by respiration leads to
image artifacts in abdominal DTI. Even in respiratory
triggered scans residual motion remains. The aim of this
study on 12 subjects was to employ non-rigid image
registration of individual echo planar DTI images of
human kidneys, which are virtually free of motion
artifacts, and to compare the variability of the
determined diffusion parameters and image blurring with
the standard processing. Significantly lower signal
variabilities and standard deviations of determined
diffusion parameters were obtained from co-registered
images, clearly demonstrating the benefit of performing
co-registration of individual EP-images in DTI
measurements of the kidney.
|
1330. |
DCE-MRI in patients with
mRCC: pilot study investigating possible biomarkers of
antiangiogenic therapy
Andrew B Gill1, Gayathri D S Anandappa2,
Andrew N Priest1, Andrew J Patterson1,
Martin J Graves1, Ilse Joubert1,
Louise M Cookson3, Kate M Fife2,
Philip S Murphy3, Duncan B Richards3,
Evis Sala1, Tim Eisen2, Duncan I
Jodrell2, and David J Lomas1
1Radiology, Addenbrooke's Hospital &
University of Cambridge, Cambridge, United Kingdom, 2Oncology,
Addenbrooke's Hospital & University of Cambridge, 3GlaxoSmithKline,
United Kingdom
This study investigated DCE-MRI indices as early
indicators of the activity of the antiangiogenic drug
bevacizumab when used in patients with metastatic renal
cell carcinoma. Two base-line and two post-treatment
examinations were performed on six patients. DCE-MRI
data was analysed using an ‘extended Tofts’ kinetic
model with a model AIF to produce parameter maps which
were then analysed to yield tumour medians. Significant
reductions, compared to the mean of the base-line
levels, were found in Ktrans and
vpin tumours 3 days after treatment. IAUGC90
values showed a significant decrease both 4 hours after
treatment and 3 days after treatment.
|
1331. |
Tracer kinetic parameters
estimated with rapid DCE-MRI in patients with
muscle-invasive cancer of the bladder are able to
distinguish between the effects of neo-adjuvant chemotherapy
and residual tumour
Stephanie Donaldson1, Bernadette Carrington2,
Suzanne Bonington2, Richard Cowan3,
Jeanette Lyons3, and David Buckley4
1Christie Medical Physics and Engineering,
The Christie, Manchester, Greater Manchester, United
Kingdom, 2Department
of Radiology, The Christie, Manchester, United Kingdom, 3Department
of Clinical Oncology, The Christie, Manchester, United
Kingdom, 4Division
of Medical Physics, University of Leeds, Leeds, United
Kingdom
Treatment of bladder cancer with chemotherapy and
radiotherapy results in inflammation which mimics
residual tumour on conventional MR images. Dynamic
contrast-enhanced (DCE-) MRI was performed in eighteen
patients following neo-adjuvant chemotherapy. Data
obtained from abnormal areas observed on conventional MR
images were analysed with a two-compartment exchange
model to obtain estimates of perfusion and permeability.
The descriptive parameter, relative signal intensity at
80 s (rSI80s) was calculated. The bladder was examined
for evidence of residual tumour and/or post-chemotherapy
effect. DCE-MRI parameters obtained in areas of residual
tumour were significantly higher than those obtained in
areas of post-chemotherapy effect.
|
|
|
Traditional
Poster Session - Body |
|
Pulmonary Imaging: UTE & Beyond
Click on
to view
the abstract pdf. Click on
to view
the poster (Not all posters are available for viewing.)
Tuesday 8 May 2012
Exhibition Hall |
10:00 - 12:00 |
|
|
1332. |
Assessment of cardiac
function and pulmonary edema by MRI following
pharmacological TRPV4 channel blockade in a murine heart
failure model
Hasan Alsaid1, Stephen C Lenhard2,
Weike Bao2, Mary V Rambo3, Alan R
Olzinski2, Gregory A Logan4, Mark
E Burgert5, James R Tunstead6,
Hilary S Eidam2, Krista B Goodman2,
Mui Cheung2, Robert N Willette2,
Kevin S Thorneloe2, and Beat M Jucker2,3
1Preclinical & Translational Imaging,
GlaxoSmithKline, King of Prussia, PA, United States, 2Heart
Failure DPU, Metabolic Pathways and Cardiovascular
Therapy Area Unit,3Preclinical &
Translational Imaging, 4Respiratory
Therapy Area Unit, 5Discovery
Analytics, 6Platform
Technology & Science
Activation of TRPV4 increases lung permeability, leading
to the formation of lung edema. GSK2193874A is a novel
TRPV4 channel blocker that inhibits TRPV4 Ca2+ flux
(in-vitro, IC50 =2nM). In this study, we tested whether
GSK2193874A could prevent and/or reverse pulmonary edema
and improve pulmonary function assessed by 1H-MRI in a
murine heart failure model. MRI results revealed
GSK2193874A significantly reduced lung water signal
intensity, lung volume and edema. However, no effect was
observed on cardiac function and remodeling. These
results suggest MRI may be used to assess the
therapeutic benefit of TRPV4 channel blockade on
pulmonary edema in heart failure.
|
1333.
|
In Vivo 1H/19F UTE Imaging
of Lung Disease
Eriko Yoshimaru1, Julio Cárdenas-Rodríguez2,
Mark D Pagel2, Robert Erickson3,4,
and Theodore Trouard1
1Biomedical Engineering, University of
Arizona, Tucson, Arizona, United States, 2Department
of Chemistry, University of Arizona, Tucson, Arizona,
United States, 3Department
of Molecular and Cellular Biology, University of
Arizona, Tucson, Arizona, United States, 4Pediatrics,
University of Arizona
Diagnosis and treatment of many illnesses could be
improved by MRI of lung inflammation and functional
compromise. However, such imaging using traditional MRI
methods is difficult. Recently, 19F MRI of
perfluorocarbon emulsions have shown sensitivity to the
presence of macrophages and monocytes in areas of
inflammation. In this work, we present 1H and 19F
spin-echo and Ultrashort TE (UTE) MRI to obtain 2D and
3D volumetric images of mouse models of cystic fibrosis
(CF) and Niemann-Pick type C (NPC) disease. The UTE
techniques used allow for motion insensitive 3D imaging
of lung tissue and inflammation-associated
perflorocarbon accumulation.
|
1334. |
1H/19F MRI of Lung
Angiogenesis with αvβ3-integrin
Targeted Perfluorocarbon Nanoparticles
Anne Schmieder1, Shelton Caruthers1,
John Stacy Allen1, Todd Williams1,
Elizabeth Wagner2, Samuel Wickline1,
and Gregory Lanza1
1Washington University Medical School, St
Louis, MO, United States, 2Johns
Hopkins University, Baltimore, MD, United States
Asthma related proliferating bronchial neovasculature
contributes to a sustained decrement in pulmonary
function. In this study, a rat model of bronchial
vascular proliferation was used to demonstrate
noninvasive, high resolution molecular imaging of lung
angiogenesis with dual 1H/19F MRI of αvβ3-targeted
nanoparticles using a commercial 3T scanner. A novel
steady state, ultrashort echo time technique was
employed with a 3D radial readout scheme. The successful
imaging of lung angiogenesis with this technique
demonstrates a clinically translatable approach to
monitor temporal-spatial changes in airway vascularity
and potentially to deliver and monitor antiangiogenic
therapy in order to ameliorate the progression of
moderate to severe asthma.
|
1335. |
Positive contrast
ultra-short echo time imaging (UTE) of infiltrating
iron-labeled macrophages for early detection of lung
inflammation in the mouse
Klaus Strobel1, Verena Hoerr1,
Florian Schmid1, Lydia Wachsmuth1,
and Cornelius Faber1
1University Hospital Münster, Münster,
Germany
Preclinical diagnosis of lung inflammation with T2* weighed
protocols after systemic application of super
paramagnetic iron oxide nanoparticles (SPIOs) is
considered impossible because of the strong intrinsic
susceptibility effects between lung parenchyma and
alveolar spaces. Here we implemented an ultra-short echo
time (UTE) sequence and successfully detected positive
contrast in the lung after systemic administration of
SPIOs in a mouse model of lung inflammation.
|
1336.
|
Effect of Image
Registration on Oxygen-Enhanced MRI of the Lung
Alexandra R Morgan1,2, Arousa Ali1,
Penny L Hubbard1,2, Geoff JM Parker1,2,
Marietta LJ Scott3, Simon S Young3,
Lars E Olsson4, Caleb Roberts1,2,
and Josephine H Naish1,2
1Imaging Science, School of Cancer and
Enabling Sciences, Manchester Academic Health Science
Centre, The University of Manchester, Manchester,
Greater Manchester, United Kingdom, 2Biomedical
Imaging Institute, The University of Manchester,
Manchester, Greater Manchester, United Kingdom, 3AstraZeneca
R&D, Alderley Park, Macclesfield, United Kingdom, 4AstraZeneca
R&D, Mölndal, Sweden
Pixel-wise analysis of pulmonary images acquired using
oxygen-enhanced magnetic resonance imaging (OE-MRI) is
challenging because of non-linear changes in shape and
size of the lung during free breathing. A new non-linear
image registration method is presented here, utilizing a
lung motion model derived on a subject-by-subject basis
from serial structural imaging. The method is shown to
be advantageous when compared with no registration and
with a 1-D linear registration, reducing error in
fitting baseline T1 maps post-registration and
alleviating motion induced signal intensity fluctuations
in dynamic OE-MRI of oxygen wash-in/-out.
|
1337. |
Investigating Regional
Lung Motion in 3D using Proton MRI and Image Registration
Methods
Alexandra R Morgan1,2, Geoff JM Parker1,2,
Tim F Cootes1,2, Marietta LJ Scott3,
and Josephine H Naish1,2
1Imaging Science, School of Cancer and
Enabling Sciences, Manchester Academic Health Science
Centre, University of Manchester, Manchester, Greater
Manchester, United Kingdom, 2Biomedical
Imaging Institute, The University of Manchester,
Manchester, Greater Manchester, United Kingdom, 3AstraZeneca
R&D, Alderley Park, Macclesfield, United Kingdom
Current diagnosis methods in lung disease are not
capable of examining local pathological changes in
respiratory dynamics and mechanical properties. We have
developed a method for investigating regional lung
motion in 3D using proton magnetic resonance imaging
(MRI). A mesh-based group-wise affine image registration
was utilised, in conjunction with rapid structural lung
imaging, to produce maps of local lung motion in
expiration. The method presented here is illustrated in
healthy volunteers.
|
1338. |
Imaging V/Q in Chronic
Thromboembolic Pulmonary Hypertension with 3He
and 1H
MRI
Helen Marshall1, David G Kiely2,
David Capener1, Martin H Deppe1,
Juan Parra-Robles1, Andrew J Swift1,
Smitha Rajaram1, Judith Hurdman2,
Robin Condliffe1, Charles A Elliot1,
and Jim M Wild1
1Academic Radiology, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom, 2Pulmonary
Vascular Disease Unit, Sheffield Teaching Hospitals
Trust
In Chronic Thromboembolic Pulmonary Hypertension
perfusion can be imaged using scintigraphy, CTPA or 1H
MRI, but assessment of ventilation is usually limited to
scintigraphy which has low spatial resolution and uses
ionising radiation. 3He
ventilation and 1H
perfusion MRI were used to image V/Q matching in six
CTEPH patients, one patient was scanned both pre and
post endarterectomy. The perfused lung volume and area
of V-Q intersection were greatly increased by
endarterectomy. V/Q MRI is useful for the assessment of
ventilation and perfusion in CTEPH, and could provide a
sensitive non-ionising means of monitoring patient
response to interventions.
|
1339. |
High resolution
morphology, ventilation, and perfusion of the human lung by 1H
imaging at 3.0 T
André Fischer1, Stefan Weick2,
Christian Oliver Ritter1, Dietbert Hahn1,
and Herbert Köstler1
1Institute of Radiology, University of
Wuerzburg, Wuerzburg, Germany, 2Department
of Experimental Physics 5, University of Wuerzburg,
Wuerzburg, Germany
This work presents a combination of retrospectively
gated lung imaging using the DC signal and Fourier
decomposition to obtain high resolution morphological
and functional information. The data from six healthy
volunteers were acquired using standard 1H
equipment without breathhold or ECG triggering on a
clinical 3.0 T MR scanner. Perfusion- and
ventilation-weighted images were successfully obtained
and could be verified by comparison to standard Fourier
decomposition (ventilation) and DCE-MRI (perfusion). In
a following step, the proposed method will be tested on
patients to investigate the diagnostic potential of this
technique.
|
1340. |
High temporal resolution
radial bSSFP sequence with nonlinear inverse reconstruction
for the measurement of the pulmonary blood inflow time using
Fourier decomposition MRI
Grzegorz Bauman1, Monika Eichinger2,
and Martin Uecker3,4
1Dept. of Medical Physics in Radiology,
German Cancer Research Center (DKFZ), Heidelberg,
Germany, 2Dept.
of Radiology, German Cancer Research Center (DKFZ),
Heidelberg, Germany, 3Biomedizinische
NMR Forschungs GmbH, Max-Planck-Institut für
biophysikalische Chemie, Göttingen, Germany, 4Electrical
Engineering and Computer Science, University of
California, Berkeley, United States
In this work we show feasibility of a radial balanced
steady-state free precession sequence with the nonlinear
inverse reconstruction for acceleration of the proton
lung image acquisition. The combination of efficient
acquisition and novel reconstruction method provides
very high temporal resolution up to 20 images per
second. This technique can be used for ventilation- and
perfusion-weighted Fourier decomposition MRI both to
improve image quality and to obtain complimentary
information regarding the blood inflow time in the
thoracic vessels and lung parenchyma. The method was
tested in a small group of volunteers and in a cystic
fibrosis patient.
|
1341. |
Physiological modelling of
a dynamic contrast-enhanced MRI extended time series in COPD
Penny L Hubbard1,2, Geoff J M Parker1,2,
Dave Singh3, Eva Bondesson4,5,
Lars E Olsson4, Lars Wigström4,
Simon S Young6, and Josephine H Naish1,2
1Imaging Sciences, Manchester Academic Health
Science Centre, The University of Manchester,
Manchester, United Kingdom, 2The
Biomedical Imaging Institute, The University of
Manchester, Manchester, United Kingdom, 3Medicines
Evaluation Unit, University Hospital Of South
Manchester, The University of Manchester, Manchester,
United Kingdom, 4AstraZeneca
R& D, Sweden, 5Semcon
Drug Development Consulting, Sweden, 6AstraZeneca
R& D, United Kingdom
We present the results of a dynamic contrast-enhanced (DCE-)
MRI study in subjects with Chronic Obstructive Pulmonary
Disease (COPD) and age-matched healthy subjects. To our
knowledge this is the first study to fit a
pharmacokinetic model to an extended dynamic
contrast-enhanced time series in this patient group.
Fitting the extended Kety model revealed reductions in
both the transfer coefficient (Ktrans)
and pulmonary blood volume (vp) in
severe COPD, but not moderate COPD. This is suggestive
of reduced perfusion with increased disease severity.
|
1342. |
Quantification of
Pulmonary Perfusion: Comparison of DCE-MRI and SEEPAGE at
3.0 T
André Fischer1, Christian Oliver Ritter1,
Dietbert Hahn1, and Herbert Köstler1
1Institute of Radiology, University of
Wuerzburg, Wuerzburg, Germany
SEEPAGE is a non-invasive non-contrast-enhanced
technique to accurately quantify pulmonary perfusion in
a single shot while requiring only short breathhold
times. DCE-MRI is the gold-standard in quantitative lung
MRI. However, it is invasive and requires longer
breathhold times to sufficiently sample the passage of
the contrast agent. No comparison of SEEPAGE to DCE-MRI
has been performed yet. Therefore, this study directly
compared quantified lung perfusion rates of four healthy
volunteers obtained with SEEPAGE and DCE-MRI. Results
demonstrate a good agreement of SEEPAGE perfusion values
with DCE-MRI. Furthermore, this work reports the first
successful application of SEEPAGE at 3.0 T.
|
1343. |
Ultrashort echo time MRI
of lung pathology in humans
Scott K Nagle1,2, Jeffrey S Nackos1,
Mark L Schiebler1, Christopher J Francois1,
Laura C Bell2, Sean B Fain1,2, and
Kevin M Johnson2
1Radiology, University of Wisconsin, Madison,
WI, United States, 2Medical
Physics, University of Wisconsin, Madison, WI, United
States
Ultrashort echo time (UTE) techniques have been used
successfully to image very short T2* tissues in the
musculoskeletal system and more recently in animal
lungs. In this work we demonstrate the feasibility of
using 3D radial UTE MRI with an echo time of 80μs to
image the lungs of sick patients with isotropic 1.25mm
spatial resolution and full-chest coverage. The method
is implemented on commercially available hardware,
requires no breath-holds and is very robust to motion.
The visualization of several different types of lung
pathology were evaluated and compared to conventional
echo time images acquired simultaneously using a
dual-echo approach.
|
1344. |
Oxygen Enhanced Lung MRI
Using 3D Radial UTE SPGR in Humans
Stanley J Kruger1, Kevin M Johnson1,
Sean B Fain1,2, Robert V Cadman1,
Laura C Bell1, and Scott K Nagle1,3
1Medical Physics, University of Wisconsin,
Madison, WI, United States, 2Biomedical
Engineering, University of Wisconsin, Madison, WI,
United States, 3Radiology,
University of Wisconsin, Madison, WI, United States
Oxygen Enhanced MRI of lung parenchyma has so far relied
on a SSFSE sequence paired with an inversion recovery to
mitigate T2* decay and provide ample contrast in the low
signal environment. Coverage is often limited, and
multiple acquisitions are required to obtain adequate
SNR. Radial 3D UTE-SPGR is a new technique in oxygen
enhanced MRI that combines oversampling the center of
k-space as well as short TE to yield a 3D isotropic
volume of oxygen enhanced signal that is robust against
cardiac motion artifact and T2* decay, while providing
full lung coverage in any orientation.
|
1345. |
Ventilation-perfusion
mismatch in COPD with or without emphysema: comparison of
functional OE-MRI and structural CT
Weijuan Zhang1,2, Penny L Hubbard1,2,
Eva Bondesson3, Lars Wigström4,
Simon S Young5, David Singh6,
Geoffrey JM Parker1,2, and Josephine H Naish1,2
1Imaging Sciences, School of Cancer &
Enabling Sciences, The University of Manchester,
Manchester, United Kingdom, 2The
Biomedical Imaging Institute, The University of
Manchester, Manchester, United Kingdom, 3Semcon
Drug Development Consulting, Lund, Sweden, 4AstraZeneca
R&D, Lund, Sweden, 5AstraZeneca
R&D, Chamwood, United Kingdom, 6University
Hospital of South Manchester Foundation Trust,
Manchester, United Kingdom
Single-slice coronal oxygen-enhanced MRI were performed
in 24 patients with chronic obstructive pulmonary
disease (COPD) and 12 healthy volunteers, from which
color-coded V/Q maps were extracted by pixelwise model
fitting. COPD lungs were then structurally classified
into emphysematous and non-emphysematous subgroups
according to percentage of low attenuation areas under
-950 Hounsfield units in matched 2D CT images. COPD
patients have considerably heterogeneous V/Q maps
whether or not emphysema is present. a significant
positive correlation between LAA% and IQR-V/Q in
emphysematous COPD (r=0.449, p=0.017), while there is no
significant correlation in non-emphysematous COPD. In
addition, there is no significant correlation between
median log10 V/Q and LAA% in either COPD group.Within
the slice, the V/Q distribution becomes more
heterogeneous with increasing emphysema, while in
non-emphysematous COPD, other factors, possibly
including airway blockage and inflammation, may be
responsible for the V/Q change. regional V/Q mismatch
whether or not emphysema is present.V/Q maps in both
types of COPD were much more heterogeneous than those in
healthy subjects, while they showed similar or mildly
lower heterogeneity in non-emphysematous COPD than in
emphysematous COPD, which demonstrates that comparative
ventilation-perfusion mismatch exists in COPD even if
there is no emphysema. To explore the potentially
different structure-function relationship in two types
of COPD, correlations between CT parameters and OE-MRI
parameters were measured. Median V/Q did not correlate
with LLA% in both COPD groups. However, inter-quartile
range of V/Q (V/QIQR), representing the extent of
heterogeneity, was fairly correlated with LLA% in
emphysematous COPD (r=0.449, p=0.017), indicating V/Q
mismatch in COPD gets worse as emphysema increases.
However, the correlation was not found in
non-emphysematous COPD. This study elucidates that
distinction between emphysematous COPD and
non-emphysematous COPD does not affect the presence of
V/Q imbalance substantially but that the relationship
between V/Q and the CT measures does vary between these
two types.
|
1346. |
T2 Mapping
of the Lung in breath-hold Time using Radial TSE Acquisition
and Nonlinear Inversion Reconstruction
Michael Völker1, Shermiyah Baguisa2,
Martin Blaimer1, Felix Breuer1,
and Peter Jakob1,3
1Magnetic Resonance Bavaria, Würzburg,
Germany, 2Department
of Physics, Ryerson University, Toronto, Canada, 3Department
of Experimental Physics 5, University of Würzburg,
Germany
We show that fast T2 relaxometry
of the human lung is feasible using an efficient radial
TSE sequence for data acquisition followed by a
model-based nonlinear reconstruction approach. T2 maps
for multiple slices were obtained in one single
breathhold of 13s.
|
|
|
Traditional
Poster Session - Body |
|
Hyperpolarized-Gas Lung Imaging
Click on
to view
the abstract pdf. Click on
to view
the poster (Not all posters are available for viewing.)
Tuesday 8 May 2012
Exhibition Hall |
10:00 - 12:00 |
|
|
1347. |
Image-based Measurement of
T2* for Dissolved-phase Xe129 in the Human Lung
John P. Mugler, III1, Talissa A. Altes1,
Iulian C. Ruset2,3, G. Wilson Miller1,
Jaime F. Mata1, Kun Qing4, Igor
Tsentalovich2, F. William Hersman2,3,
and Kai Ruppert1
1Radiology & Medical Imaging, University of
Virginia, Charlottesville, VA, United States, 2Physics,
University of New Hampshire, Durham, NH, United States, 3Xemed,
LLC, Durham, NH, United States, 4Biomedical
Engineering, University of Virginia, Charlottesville,
VA, United States
The T2* of dissolved-phase Xe129 in the lung was
measured in three healthy subjects. Median T2* values
ranged between 2.0 and 2.3 ms.
|
1348.
|
Observation of
gravitational dependence of regional fractional ventilation
in human lungs with 2D and 3D multi-breath washout imaging
of 3He
and 129Xe
Felix Clemens Horn1, Martin Heiner Deppe1,
Helen Marshall1, Graham Norquay1,
Juan Parra-Robles1, and Jim Wild1
1University of Sheffield, Sheffield, South
Yorkshire, United Kingdom
The effects of gravity in multiple-breath inert gas
washout MRI of hyperpolarised 3He
and 129Xe
with 2D and 3D imaging are demonstrated in a volunteer
at 1.5 T. To compare different washout experiments the
regional fractional ventilation factor r (=%
of gas exchanged per breath) was used. It is seen that
the gravitational effects are irrespective of imaging
sequence and gas type being used and the offset between r-values
of different experiments is likely to be dependent upon
the gas used, on sequence and respirational volume.
|
1349. |
Detection of a Long-T2
Dissolved-phase Xe129 Component in the Human Chest
Kai Ruppert1, Talissa A. Altes1,
Iulian C. Ruset2, G. Wilson Miller1,
Jaime F. Mata1, Kun Qing1, Igor
Tsentalovich3, F. William Hersman2,3,
and John P. Mugler III1
1University of Virginia, Charlottesville, VA,
United States, 2Xemed
LLC, Durham, NH, United States, 3University
of New Hampshire, Durham, NH, United States
The T2* of hyperpolarized xenon-129 dissolved in lung
tissue is about 2 ms, which greatly reduces the
resulting signal amplitude for most gradient-echo pulse
sequences. In this work, we measured the T2 of
dissolved-phase xenon using a global CPMG echo-train
spectroscopic pulse sequence and identified a large
(85%) signal component with a T2 of ~18 ms and a smaller
(15%) component with a T2 of ~400 ms. The long T2
component would be suitable for direct imaging using a
spin-echo sequence. However, due to its small amplitude,
an improvement in image quality over existing
gradient-echo pulse sequences remains doubtful.
|
1350. |
Reproducibility of
Hyperpolarized Xenon-129 Magnetic Resonance Imaging of
Chronic Obstructive Pulmonary Disease
Nikhil Kanhere1,2, Miranda Kirby1,3,
Andrew Wheatley1, Alexei Ouriadov1,
Giles E Santyr1,3, David G McCormack4,
and Grace Parraga1,2
1Robarts Research Institute, London, Ontario,
Canada, 2Graduate
Program in Biomedical Engineering, The University of
Western Ontario, 3Medical
Biophysics, The University of Western Ontario, 4Division
of Respirology, Department of Medicine, The University
of Western Ontario
The objective was to determine the reproducibility of
hyperpolarized xenon-129 (129Xe) magnetic
resonance imaging (MRI) measurements within the same day
(5-min rescan) and after 7-days in chronic obstructive
pulmonary disease (COPD) ex-smokers. For all subjects
(n=9) there was no significant difference for 129Xe
ventilation defect percent (VDP) between the scan and
5-min rescan (p=.80) nor was there a significant
difference between all three time-points for the three
COPD subjects that returned for 7-day imaging (p=.06).
These findings suggest that 129Xe
is a highly reproducible gas and a feasible alternative
to 3He
MRI with strong translational potential in COPD studies.
|
1351. |
Cardiac triggering
suppresses heart-motion artifacts in hyperpolarized-gas lung
pO2 maps
G. Wilson Miller1, John P. Mugler III1,
Talissa A. Altes1, Jaime F. Mata1,
Kai Ruppert1, F. William Hersman2,
Jan Distelbrink2, and Iulian C. Ruset2
1Radiology and Medical Imaging, University of
Virginia, Charlottesville, VA, United States, 2Xemed
LLC, Durham, New Hampshire
Lung pO2 maps
generated from T1-weighted hyperpolarized-gas
MR images often show unphysiological pO2 values
in the vicinity of the heart. These anomalous values are
thought to result from cardiac motion during the
breath-hold acquisition. We demonstrate that such
artifacts can largely be eliminated by synchronizing
image acquisition with the cardiac cycle.
|
1352. |
Lung Morphometry using
Hyperpolarized Xenon-129: Preliminary Experience
Kai Ruppert1, James D. Quirk2,
John P. Mugler III1, Talissa A. Altes1,
Chengbo Wang1, G. Wilson Miller1,
Iulian C. Ruset3,4, Jaime F. Mata1,
F. William Hersman3,4, and Dmitriy A.
Yablonskiy2
1University of Virginia, Charlottesville, VA,
United States, 2Washington
University, St. Louis, MO, United States, 3Xemed
LLC, Durham, NH, United States, 4University
of New Hampshire, Durham, NH, United States
The recently described helium-3 (He3) lung-morphometry
technique, which is based on in-vivo MR measurements of
the diffusivity of hyperpolarized He3 gas in the lung,
provides information on parameters commonly used by lung
physiologists to characterize lung morphometry. However,
due to the high cost and limited supply of He3, lung
morphometry with hyperpolarized xenon-129 (Xe129) might
become an attractive alternative for widespread
application. In this work we demonstrate the feasibility
of Xe129 lung morphometry and present results that
indicate a good agreement between the findings with He3,
Xe129 and histology.
|
1353.
|
Automatic Respiratory Gas
Delivery Device for Noninvasive Administration of
Hyperpolarized Gaseous Contrast Agents to Consciously
Breathing Subjects
Kiarash Emami1, Hooman Hamedani1,
Biao Han1, Yinan Xu1, Stephen J.
Kadlecek1, Masaru Ishii2, and
Rahim R. Rizi1
1Radiology, University of Pennsylvania,
Philadelphia, PA, United States, 2Otolaryngology
- Head and Neck Surgery, Johns Hopkins University,
Baltimore, MD, United States
The design of an automatic MRI-compatible respiratory
gas mixing, delivery and monitoring device capable of
administering a predefined tidal volume and
concentration of gaseous contrast agents to consciously
breathing subjects is described. This system divides the
mixture of hyperpolarized gas and oxygen over several
breaths for multi-breath imaging protocols or
oxygen-weighted MRI, queues the subject (without the
risk of over-inflating the lungs) and synchronizes image
acquisition with MRI scanner. This device eliminates the
need for operator supervision by responding to subject’s
voluntary respiratory effort, and makes it possible to
maintain a respiratory pattern very similar to normal
breathing.
|
1354. |
A Comparison of
Hyperpolarized Helium-3 and Xenon-129 MR Ventilation Imaging
in Cystic Fibrosis
Talissa A Altes1, John P Mugler1,
Craig Meyer2, Jaime H Mata1, Peter
Komlosi1, Deborah Froh3, Grady
Wilson Miller1, F William Hersman4,
Iulian C Russet4, Igor Tsentalovich4,
Eduard E de Lange1, Martyn C Botfield5,
and Mac Johnson5
1Radiology, University of Virginia,
Charlottesville, VA, United States, 2Boimedical
Engineering, University of Virginia, Charlottesville,
VA, United States, 3Pediatric
Pulmonology, University of Virginia, Charlottesville,
VA, United States, 4Xemed,
Durham, NH, United States, 5Vertex
Pharmaceuticals Incorporated, Cambridge, MA, United
States
Summary: Ventilation MRI of the lung has been performed
with hyperpolarized helium-3 and xenon-129. It is not
known whether the distribution within the lung of
inhaled xenon-129, which has an atomic weight 43 times
that of helium-3, is different from that for helium-3.
In this study of 6 subjects with cystic fibrosis (CF),
the size, location, and relative severity of the defects
were nearly identical with helium-3 and xenon-129 for
most subjects. In a few subjects the defects were more
conspicuous, larger, and/or more numerous with
xenon-129, which suggests xenon-129 may be more
sensitive to areas of partial airflow obstruction.
|
1355. |
Hyperpolarized Helium-3 MR
Imaging of a Non-Sedated Infant: A Proof-of-Concept Study
Talissa A Altes1, Craig H Meyer2,
Jaime H Mata1, Deborah Froh3, Alix
Paget-Brown3, Sean Fain4, Eduard E
de Lange1, Grady Wilson Miller1,
Karen Mooney1, Gordon D Cates5,
Martyn C Botfield6, Mac Johnson6,
and John P Mugler1
1Radiology, University of Virginia,
Charlottesville, VA, United States, 2Boimedical
Engineering, University of Virginia, Charlottesville,
VA, United States, 3Pediatrics,
University of Virginia, Charlottesville, VA, United
States, 4Radiology,
University of Wisconsin, Madison, WI, United States, 5Physics,
University of Virginia, Charlottesville, VA, United
States,6Vertex Pharmaceuticals Incorporated,
Cambridge, MA, United States
As a prelude to clinical studies of infants with lung
disease, the purpose of this study was to develop an
acquisition strategy and hyperpolarized helium-3 (HHe)
gas-delivery methods to enable imaging of non-sedated
infants. HHe MRI was performed in a single non-sedated,
non-restrained, healthy infant, age 13 months, using a
spiral-based acquisition and a simple HHe gas-delivery
system. The short acquisition time of 0.12 s per slice
enabled imaging of a moving infant with little motion
artifact. Similar to prior results in healthy older
children and young adults, the healthy infant had
homogeneous ventilation on HHe MRI.
|
1356. |
Fast Synchronous 3He/1H
Dynamic Lung Imaging
Salma Ajraoui1, and Jim M Wild1
1University of Sheffield, Sheffield,
Yorkshire, United Kingdom
In this work, dynamic 3He and 1H images were acquired in
a synchronised scan during inhalation providing regional
gas flow with spatially and temporally registered lung
anatomy motion. Lung ventilation is very fast (air
reaches lung periphery within 1s) and demands fast
sequences that can capture the rapid flow of 3He gas in
lung airways. Compressed Sensing (CS) was used to assess
the feasibility of accelerated synchronous 3He/1H
acquisition.
|
1357. |
High-quality Ventilation
Imaging of the Human Lung using 100 ml of Helium-3
John P. Mugler, III1, Karen E. Mooney2,
Talissa A. Altes1, Jaime F. Mata1,
Kun Qing3, Eduard E. de Lange1,
William A. Tobias2, James R. Brookeman1,
Gordon D. Cates, Jr.2, and G. Wilson Miller1
1Radiology & Medical Imaging, University of
Virginia, Charlottesville, VA, United States, 2Physics,
University of Virginia, Charlottesville, VA, United
States, 3Biomedical
Engineering, University of Virginia, Charlottesville,
VA, United States
The purpose of this study was to perform a preliminary
assessment of the quality of helium-3 (He3) ventilation
MR images that can be obtained with a He3 dose of only
100 ml by combining increased polarization with a
balanced steady-state free-precession (TrueFISP)
acquisition. High-quality images, with SNR values
ranging between 28 and 43, were obtained in five healthy
subjects.
|
1358. |
Direct Imaging of Delayed
and Collateral Ventilation in COPD using Hyperpolarised 3He
MRI
Helen Marshall1, Martin H Deppe1,
Juan Parra-Robles1, Sue Hillis2,
Catherine Billings2, Smitha Rajaram1,
Andrew J Swift1, Sam R Miller3,
Joanna H Watson3, Jan Wolber4,
David A Lipson5, Rod Lawson2, and
Jim M Wild1
1Academic Radiology, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom, 2Respiratory
Medicine, Sheffield Teaching Hospitals NHS Trust, 3GlaxoSmithKline,
Stockley Park, 4GE
Healthcare, Amersham, 5GlaxoSmithKline,
King of Prussia
Collateral ventilation is an important mechanism in
Chronic Obstructive Pulmonary Disease but limited
observations of it have been demonstrated in vivo. 10
COPD patients were scanned with hyperpolarised. 3He
MRI using a time-resolved 3D sequence. 3He
was observed moving into lung regions which were
initially non-ventilated during a static breath-hold.
The images show direct visual evidence of delayed gas
ventilation in what we believe to be collateral
ventilation in COPD. Delayed-filling of peripheral
regions was also observed in some patients which may be
due to increased flow resistance in the small airways.
|
1359. |
HYPERPOLARIZED HELIUM-3
MRI DETECTS THE EFFECTS OF A CFTR POTENTIATOR (IVACAFTOR)
THERAPY IN SUBJECTS WITH CYSTIC FIBROSIS AND THE G551D
MUTATION
Talissa A Altes1, Mac Johnson2,
John P Mugler1, Deborah Froh3,
Lucia Flors1, Grady Wilson Miller1,
Jaime H Mata1, Carlos L Salinas1,
Nick Tustison1, Po-Shun Lee2, Tao
Song2, Karl Yen2, Eduard E de
Lange1, and Martyn C Botfield2
1Radiology, University of Virginia,
Charlottesville, VA, United States, 2Vertex
Pharmaceuticals Incorporated, Cambridge, MA, United
States, 3Pediatric
Pulmonology, University of Virginia, Charlottesville,
VA, United States
This study to evaluate the ability of hyperpolarized
helium-3 MR ventilation imaging to detect the effects of
treatment with ivacaftor, a CFTR potentiator,
demonstrated a rapid onset of improvement in lung
ventilation with treatment and equally rapid return to
near baseline ventilation following cessation of
treatment. Eight subjects with CF were imaged on 5
different days, 2 weeks apart (Days 0, 14, 28, 42, and
56), and were treated with Ivacaftor from Days 14 to 42.
Interim data analysis has been conducted on the first 4
subjects in the study, although all 8 subjects have
completed the trial.
|
1360. |
Collection of Helium-3 for
Recycling from Human Imaging Studies
Karen E. Mooney1, Walter H. Whitlock2,
Thomas C. Hyde2, John P. Mugler III3,
Talissa A. Altes3, Jamie F. Mata3,
Gordon D. Cates Jr.1,3, Eduard E. de Lange3,
and G. Wilson Miller3
1Physics, University of Virginia,
Charlottesville, Virginia, United States, 2Conservation
Design Services, Inc., Chapel Hill, NC, 3Radiology,
University of Virginia
Our group has begun a program to collect 3-helium from
human imaging studies for future recycling. The
materials and method of collection are described and gas
analysis results are presented.
|
1361. |
Unshielded and Asymmetric
RF Transmit Coil for Hyperpolarized 129Xe Human Lung Imaging
at 3.0 T
Adam Farag1, Jian Wang2, Alexei
Ouriadov1, Grace Parraga1,3, and
Giles Santyr1,3
1Imaging Research Laboratory, Robarts
Research Institute, London, Ontario, Canada, 2Applied
Science Laboratory, GE Healthcare, 3Dept.
of Medical Biophysics
The revolution of the MRI today made it more possible to
achieve the impossible. New hardware designs are
certainly part of this, and in particular unconventional
RF coils.
|
|
|
Traditional
Poster Session - Body |
|
Novel Body MR Technologies
Click on
to view
the abstract pdf. Click on
to view
the poster (Not all posters are available for viewing.)
Tuesday 8 May 2012
Exhibition Hall |
10:00 - 12:00 |
|
|
1362.
|
Assessment of Liver Fat
With T2 Correction Using Magnetic Resonance Spectroscopic
Imaging
Jian-Jia Chiu1, Yi-Ru Lin1, and
Shang-Yueh Tsai2,3
1Department of Electronic Engineering,
National Taiwan University of Science and Technology,
Taipei, Taiwan, 2Graduate
Institute of Applied Physics, National Chengchi
University, Taipei, Taiwan, 3Reasearch
Center for Mind, Brain and Learning, National Chengchi
University, Taipei, Taiwan
Early detection of non-alcoholic fatty liver disease can
prevent further complications such as steatohepatitis,
fibrosis and cirrhosis. Previous we have shown that
proton echo planar spectroscopic imaging (PEPSI) is able
to detect spatial distribution of liver fat content.
Here we further investigated the influence of T2
relaxation effects. Non-water suppressed liver spectra
were obtained using PEPSI sequence. PEPSI scans were
repeated 8 times to observe the reproducibility of T2
correction. Our results showed that hepatic fat content
distribution with T2 correction can be achieved in less
than 3 minutes with our protocol. And the measured fat
content is highly reproducible.
|
1363. |
Simultaneous measurement
of fat content and phosphorous compounds of liver in middle
aged to elderly healthy subjects
Alessandra Laufs1, Roshan Livingstone1,
Sabine Link1, Bettina Nowotny1,
Birgit Klueppelholz2, Guido Giani2,
Jürgen Bunke3, Michael Roden1,4,
and Jong-Hee Hwang1
1Institute for Clinical Diabetology, German
Diabetes Center, Düsseldorf, Germany, 2Institute
for Biometry and Epidemiology, German Diabetes Center,
Düsseldorf, Germany,3Philips Healthcare,
Hamburg, Germany, 4Department
of Metabolic Diseases, University Clinics Düsseldorf,
Heinrich Heine University, Düsseldorf, Germany
In order to evaluate relations between age, liver fat,
and ATP in the liver in 51 healthy subjects over 40
years old, liver fat by 1H
MRS and 31P
MRS of liver using 3D ISIS were obtained on a 3T
scanner. As a result, the mean values of -ATP/Pi
ratios and the liver fat content were 1.25±0.29 and
4.5±6%. ATP/Pi correlated with liver fat (r=0.29,
p<0.05), and liver fat correlated with age(r=0.36,
p<0.05). BMI did not correlate with ATP/Pi.
|
1364. |
Echo time compensation
adds robustnes to symmetrically sampled two point dixon
imaging
Thobias Romu1,2, Louise Elander3,
Magnus Borga1,2, and Olof Dahlqvist Leinhard2,4
1Department of Biomedical Engineering,
Linköpings Universitet, Linköping, Ostergotland, Sweden, 2CMIV,
Linköpings Universitet, Linköping, Sweden, 3County
Council of Ostergotland, Linköping, Sweden, 4Depts
of Radiation Physics, Linköping University and Radiation
Physics, UHL County Council of Ostergotland, Linköping,
Sweden
When leaving the comfortable zone of the first OP/IP
echo’s small adjustments in TE can make a huge
difference for symmetrically sampled Dixon imaging.
Fortunately on the fly compensation is relatively easy
using a short single voxel spectroscopy scan and a model
of the fat/water interference. The method is tested
using the second OP and third IP echo, both in vitro and
in vivo.
|
1365. |
Performance of Chemical
Shift-based Wate-fat Separation with Self-calibrated Fat
Spectrum is Sensitive to Echo Times
Xinwei Shi1, Haining Liu1, Chun
Yuan1,2, and Hua Guo1
1Center for Biomedical Imaging Research,
Department of Biomedical Engineering, School of
Medicine, Tsinghua University, Beijing, China, 2Department
of Radiology, University of Washington, Seattle, WA,
United States
IDEAL (Iterative decomposition of water and fat with
echo asymmetry and least-squares estimation) algorithm
incorporating with multi-peak fat spectral modeling can
provide complete water-fat separation, and thus is an
effective way for fat quantification or fat suppression.
Since the fat spectra vary in different tissue, a
self-calibration method is needed to accurately measure
the fat frequency model in the interested region. In
this work, we analyze the performance of multi-peak
IDEAL algorithm with self-calibrated fat spectrum by
simulation, phantom and in vivo experiments and find
optimized echo time increments which provide reliable
water-fat separation.
|
1366. |
Optimal TE1 and
Echo Time Shift Combination for R2* Estimation
using T2* IDEAL
Haining Liu1, Xinwei Shi2, Chun
Yuan3, and Hua Guo2
1Center for Bio-Medical Imaging Research,
Tsinghua University, Beijing, Beijing, China, 2Tsinghua
University, 3Department
of Radiology, University of Washington, Seattle, WA
Noise performance for chemical-shift based multi-point
water-fat separation method is affected by the selection
of echo time combination. The purpose of this work is to
find optimal TE1 and deltaTE combinations through Monte
Carlo simulations and phantom experiments. The variance
of R2* estimation using T2* IDEAL algorithm based on the
multi-peak fat spectrum is evaluated. The results from
the simulations and experiments are consistent with each
other, and an optimal TE1 and deltaTE combination range
is found. The limitation of Cramer-Rao bound theory on
the evaluation of R2* variance also discussed.
|
1367. |
Multiecho 2-Point Dixon (mDIXON)
Imaging as an Alternative to Separate 2D Chemical Shift
Imaging and 3D Fat-Suppressed T1-weighted Sequences for
Gadolinium Enhanced Imaging
R D Sims1, Q Yuan1, G Khatri1,
P T Weatherall1, R Batz1, S Zhang2,
I Pedrosa1, and N M Rofsky1
1Radiology, UT Southwestern Medical Center,
Dallas, Texas, United States, 2Clinical
Sciences, UT Southwestern Medical Center
The feasibility of the multiecho 2-Point Dixon (mDIXON)
technique to produce images comparable to conventional
3D fat suppressed T1weighted gradient echo (eTHRIVE)
images, while eliminating the need for separate 2D
chemical shift imaging, has been shown. We performed a
multi-parametric comparison of the latest version of
mDIXON to our previous standard 2D and 3D T1weighted
techniques. Our results confirm a statistically
significant improvement in homogeneity of fat exclusion
and reduction of artifacts compared to eTHRIVE, as well
as improved relative signal and contrast, while reducing
breath hold duration and overall scan time.
|
1368. |
Novel strategy to
differentiate water and lipid composition
Qiong Ye1, Yuan Mei2, and Markus
Rudin1,3
1Institute for Biomedical Engineering,
Zürich, Zürich, Switzerland, 2Nuclear
Science Division,Lawrence Berkeley National Laboratory,
Berkeley, California, United States,3Institute
of Pharmacology and Toxicology, Zürich, Switzerland
Magnetic resonance imaging at different echo times are
acquired from phantom and neck in ob/+ control mice in a
9.4T system. In this work, Fourier Transform was applied
at TEs to differentiate individual peaks. Results from
phantom are very promising. Derived results from neck of
ob/+ control mouse are in good agreement with theory
also. From the spatial distribution of individual peaks,
this method is able to differentiate water and lipid
composition. More images are required for decent
spectral resolution.
|
1369. |
Investigating Alterations
in Hepatic ATP levels following Fructose and
Fructose+Glucose Ingestion: A Simple Non-invasive Technique
to Assess Liver Function Using 31P
MRS
Stephen James Bawden1, Mary C Stephenson2,
Luca Marciani3, Guruprasad P Aithal3,
Ian A Macdonald3, Penny A Gowland2,
and Peter G Morris2
1SPMMRC, University of Nottingham,
Nottingham, Nottinghamshire, United Kingdom, 2SPMMRC,
University of Nottingham, 3Nottingham
Digestive Diseases Biomedical Research Unit, University
of Nottingham
Fructose metabolism is known to deplete hepatic ATP
stores due to unregulated phosphorolation. In previous
studies rate of ATP replenishment following fructose
infusion as measured using 31P Magnetic Resonance
Spectroscopy has been inversely correlated with
steatosis in non alcoholic fatty liver disease (NAFLD)
and with BMI. In this pilot study we show ATP depletion
and recovery following oral fructose intake (equivalent
sugar content ~2 cans of coke). Results are more
consistent across subjects when fructose is ingested
with glucose (1:1 ratio) due to decreased variation in
intestinal absorption rates
|
1370. |
Equilibrium contrast MRI
measurement of tissue extracellular volume of distribution
in normal volunteers using ShMOLLI T1 quantification
Steve Bandula1, Dan Sado2, Jason
Yeung3, Catherine Morgan3, Shonit
Punwani3, Stuart Taylor3, Stefan
Piechnik4, and James Moon5
1Centre for Medical Imaging, University
College London, London, London, United Kingdom, 2The
Heart Hospital, London, 3University
College London, 4University
of Oxford,5The Heart Hospital Imaging Centre,
The Heart Hospital, London
Equilibrium MRI (EQ-MRI) is a new non-invasive technique
which has been shown to accurately quantify the
extracellular volume. It may provide a useful technique
for assessment of diseases which cause a diffuse
expansion of the extracellular space. We used EQ-MRI
with ShMOLLI T1 mapping to measure the extracellular
volume within various tissues in 38 normal volunteers.
Measured values in several tissues had narrow
interquartile ranges. Values were also similar to those
quoted in the literature, measured using Dynamic
Contrast Enhanced MRI (DCE-MRI). EQ-MRI may provide a
useful tool for discrimination between normal and
diseased tissue.
|
1371.
|
A non-invasive and early
diagnosis of primary scelerosing cholangitis using MR
spectroscopy
Sanaz Mohajeri1,2, Tedros Bezabeh1,
Scott B. King1, Omkar B. Ijare1,
M.A. Thomas3, Gerald Minuk2,
Jeremy Lipschitz2, Allan B. Micflikier2,
Iain Kirkpatrick2, Lawrence Ryner1,
and Ian C.P. Smith1
1National Research Council, Institute for
Biodiagnostics, Winnipeg, Manitoba, Canada, 2University
of Manitoba, Winnipeg, Manitoba, Canada, 3University
of California, Los Angeles
Cholestasis results from failure to clear bile from the
liver into the duodenum. Prolonged cholestasis results
in accumulation of bile salts and hepatocellular damage.
Phosphatidylcholine and glycine/taurine conjugated bile
acids may play a role in the pathophysiology of
cholestasis. Primary Scelerosing Cholangitis (PSC) is a
chronic cholestatic liver disorder with inflammation,
narrowing and finally obstruction of bile ducts.
Considering the success of in vivo 1-H MRS in detecting
human bile components, we are comparing in this study
1-D and 2-D spectra of human bile in healthy volunteers
and PSC patients obtained using a 3T clinical scanner
and our home-built receive array coil.
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1372. |
Magnetic Resonance
Spectroscopic Evidence for Pancreaticobiliary Reflux in
Hepatobiliary Malignancies
Omkar B. Ijare1, Tedros Bezabeh1,
Nils Albiin2, Annika Bergquist2,
Urban Arnelo2, Matthias Löhr2,
Alexey Shiryaev3, B. S. Somashekar4,
G.A. Nagana Gowda4, V.K. Kapoor5,
C.L. Khetrapal4, and Ian C.P. Smith1
1National Research Council Institute for
Biodiagnostics, Winnipeg, Manitoba, Canada, 2Karolinska
University Hospital, Karolinska Institutet, Stockholm,
Sweden, 3Norwegian
PSC Research Center, Oslo University Hospital
Rikshospitalet, Oslo, Norway, 4Centre
of Biomedical Magnetic Resonance, SGPGIMS Campus,
Lucknow, India, 5Sanjay
Gandhi Post-Graduate Institute of Medical Sciences,
Lucknow, India
Pancreaticobiliary (PB) reflux has been considered to be
a potential risk factor for the carcinogenesis of bile
ducts and gallbladder (GB). Previous ex
vivo studies
tested the suitability of MRS for the detection of PB
reflux through the analysis of bile. In this study, we
analyzed bile samples from patients with
cholangiocarcinoma (n = 3) and GB cancer (n = 7) to
determine if any of these patients possess
regurgitation. We observed this phenomenon in 1/3
cholangiocarcinoma and 5/7 GB cancer patients,
supporting the fact that PB reflux is a risk factor for
the carcinogenesis of bile ducts and GB.
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1373. |
1H-MRS of
Pancreatic Metabolites at 3T
Ronald Ouwerkerk1, and Ahmed Medhat Gharib2
1Metabolic Imaging Branch, NIDDK/NIH,
Bethesda, MD, United States, 2Metabolic
Imaging Branch, NIH/NIDDK, Bethesda, MD, United States
Metabolites in the pancreas of healthy human subjects
were measured with single volume PRESS 1H-MRS.
In one subject the T2 relaxation
times for lipid, choline and water were determined.
Breath hold B0 field mapping improved spectral quality
and navigator gated suppression of breathing motion
helped avoid spurious lipid signals from surrounding
tissues. Spectra contained signals of choline at 3.2
ppm, creatine at 3.0 ppm, and possibly glycerol, glucose
or glycogen. The concentration of choline was 17.5±7.0
mmol/l (N=7, range 7.4-25.1). The T2 relaxation
times for lipid choline and water were 101, 98 and 48 ms
respectively in one subject.
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1374. |
Optimization and
Characterization of Two-Dimensional Correlated Spectroscopy
of Transplanted Kidney
Alexander Peter Lin1, Sai Merugumala1,
Saadallah Ramadan2, Huijun Liao1,
Paolo Fiorina3, Anil Chandraker4,
and Carolyn Mountford1,2
1Radiology, Center for Clinical Spectroscopy,
Brigham and Women's Hospital, Boston, MA, United States, 2Centre
for MR in Health, University of Newcastle, Callaghan,
New South Wales, Australia, 3Transplant
Research Center, Children’s Hospital Boston, Boston, MA,
United States, 4Renal
Division, Brigham and Women's Hospital, Boston, MA,
United States
There is a need to identify early biomarkers of
transplanted kidney dysfunction that are non-invasive.
This study describes the optimization of one-dimensional
and novel two-dimensional magnetic resonance
spectroscopy methods to identify such biomarkers. The
results showed that acquisition using a phased array
torso coil, weak water suppression with water reference,
voxel size of 13.5cc, and 2D COSY scan time of 11
minutes provided metabolite measurements of choline,
triglycerides, unsaturated fatty acids, olefinic fat,
methylene and methyl fat resonances. These results
provide the basis for future studies to determine the
potential of these metabolic biomarkers in early
detection and treatment monitoring.
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1375. |
Motion Artifact Removal by
Retrospective Resolution Reduction (MARs): Combination with
GRAPPA Acceleration and Clinical Assessment of Image Quality
Candice A. Bookwalter1, Michael W. Harrell2,
Nicole Seiberlich3, Smitha Thomas1,
Raj Mohan Paspulati1, Jeremiah A. Heilman4,
Mark A. Griswold1,3, and Vikas Gulani1,3
1Department of Radiology, University
Hospitals Case Medical Center/Case Western Reserve
University, Cleveland, OH, United States, 2School
of Medicine, Case Western Reserve University, Cleveland,
OH, United States, 3Department
of Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States, 4Quality
Electrodynamics, Mayfield Village, OH, United States
The automatic and retrospective method of Motion
Artifact Removal by Retrospective Resolution Reduction (MARs)
is evaluated in conjunction with parallel imaging time
acceleration in both simulation and patient data. MARs
uses GRAPPA navigators to detect motion corrupted data
and subsequently removes corrupted data to obtain a
motion artifact free yet lower resolution image. The
MARs method is shown to work robustly with parallel
imaging time acceleration. Image evaluation was
performed using alternate force choice ratings. MARs
corrected images were shown to be preferred over
uncorrected images.
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1376. |
Clinical Evaluation of
CAIPIRINHA: Comparison against a GRAPPA Standard
Michael W. Harrell1, Katherine L. Wright2,
John Jesberger1,3, Luis Landeras1,3,
Dean Nakamoto1,3, Smitha Thomas1,3,
Dominik Nickel4, Randall Kroeker4,
Mark A. Griswold2,3, and Vikas Gulani1,3
1School of Medicine, Case Western Reserve
University, Cleveland, OH, United States, 2Dept.
of Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States, 3Dept.
of Radiology, University Hospitals of Cleveland and Case
Western Reserve University, Cleveland, OH, United
States, 4Siemens
Medical Solutions, Erlangen, Germany
CAIPIRINHA (Controlled Aliasing In Parallel Imaging
Results IN Higher Acceleration) is an imaging technique
that modifies aliasing artifacts during image
acquisition, which potentially allows for a more robust
parallel imaging reconstruction with fewer aliasing
artifacts. Here this was tested by comparing CAIPIRINHA
against a clinically standard GRAPPA acquisition for
highly accelerated breath hold liver scans. Evaluation
of the image quality of CAIPIRINHA by three blinded,
untrained radiologists demonstrated a statistically
significant improvement in clinical image quality in
comparison to a standard GRAPPA.
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1377. |
Abdominal Motion Control
in Breath-hold MRI using Audiovisual Biofeedback
Taeho Kim1, and Paul Keall1
1Radiation Physics Laboratory, Unviersity of
Sydney, Camperdown, NSW, Australia
The quality of the radiation treatments can be
compromised by involuntary respiratory motion, which can
reduce image quality and tumor control (4-5% dose
variation per 5 mm tumor excursion). Respiratory gating
and breath-hold methods for respiratory
motion-compensation are practically useful, but
respiratory gating increases scan time and breath-hold
requires the patient¡¯s full cooperation during the
scan. The aim of this study is to develop a novel
respiratory motion control system using audiovisual (AV)
biofeedback combined with abdomen MRI and to demonstrate
improved abdominal position reproducibility and reduced
motion artifacts in breath-hold MRI.
|
1378. |
Lamellar liquid crystal
phantoms for MT- calibration and quality control in clinical
studies
S. D. Swanson 1, D. I. Malyarenko 1,
P. Schmiedlin-Ren 2, J. Adler 3, K.
Helvie 2, L. Reingold 2, M. M.
Al-Hawary 1, and E. Zimmerman 2
1Department of Radiology, University of
Michigan, Ann Arbor, Michigan, United States, 2Department
of Internal Medicine:Gastroenterology, University of
Michigan,3Department of Pediatrics and
Communicable Disease, University of Michigan
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1379. |
Monitoring of the blood
supply to artificial cavity used as a site for pancreatic
islet transplantation
Daniel Jirak1,2, Jan Kriz1, Eva
Vodraskova1, Klara Zacharovova1,
Frantisek Saudek1, and Milan Hajek1
1Institute for Clinical and Experimental
Medicine, Prague, Czech Republic, 21st
Medical Faculty, Institute of biophysics and
informatics, Charles University, Prague, Czech Republic
To improve transplantation outcome, artificially created
sites for cell transplantation have gained attention.
The aim of our study was to evaluate the blood supply of
the artificial cavities for islet transplantation in a
preclinical rat model. Two biocompatible scaffolds were
implanted subcutaneously and into greater omentum of the
same animal. The blood supply of these devices was
assessed by dynamic contrast–enhanced magnetic resonance
imaging within four weeks following implantation. Our
results indicate that artificial device implanted into
greater omentum possesses superior blood supply for the
transplanted cells and optimal time for cell
transplantation is one week after implantation.
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