Room 355 EF

10:30 - 12:30

Moderators:

Grzegorz Bauman, Jens Vogel-Claussen

Peter Caravan¹, Yan Yang¹, Roshini Zachariah², David E. Sosnovik¹, Guangping Dai¹, Bryan Fuchs², and Michael Lanuti^2
1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Surgery, Massachusetts General Hospital, Boston, MA, United States

Pulmonary fibrosis is a devastating disease with poor clinical outcomes. We show that ultrashort TE imaging with a collagen-targeted gadolinium-based MR probe can specifically identify pulmonary fibrosis in a mouse model of disease.

Andrea Bianchi¹, Annaig Ozier¹, Olga Ousova¹, Gérard Raffard², and Yannick Crémillieux^1
1Cardio-Thoracic Center of Bordeaux, University of Bordeaux Segalen, Bordeaux, France, France, ²Centre de Résonance Magnétique des Systèmes Biologiques, University of Bordeaux Segalen, Bordeaux, France, France

Ultra-short echo time (UTE) MRI was already shown to be appropriate for the quantification of the peribronchovascular inflammation typical of the first phase of the chosen ovalbumin model of asthma. The high quality of the images indicated the possibility of extending the protocol until the last phases of the model, in order to assess also the remodeling associated with the disease. We present here an UTE proton MRI high-resolution investigation of a chronic model of asthma in mice whose purpose is to longitudinally assess all the main hallmarks of the asthma model (including bronchial remodeling) using a fully non-invasive approach.

Jim M. Wild¹, Helen Marshall¹, Xiaojun Xu¹, Graham Norquay¹, Steven Parnell¹, Matthew Clemence², Paul Griffiths¹, and Juan Parra-Robles^1
1Academic Radiology, University of Sheffield, Sheffield, Yorkshire, United Kingdom, ²Philips Medical Systems, Best, Netherlands, Netherlands

The purpose of this work was development of methods for the acquisition, in the same breath-hold, of lung images from two hyperpolarized gases (3He and 129Xe) with simultaneous registered anatomical 1H MR images of lung structure.

Yogesh K. Mariappan¹, David L. Levin¹, Kevin J. Glaser¹, Richard Leroy Ehman¹, and Kiaran P. McGee^1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States

It has been shown that pulmonary MR Elastography (MRE) can resolve the effective stiffness of human lung parenchyma using a short-TE spin echo (SE) technique. In this work, estimation of true parenchymal stiffness is described and involves the application of a SE EPI MRE sequence and GRE lung density estimation technique. This approach was evaluated on a preserved lung specimen and on healthy human volunteers. Stiffness values obtained with the EPI-MRE sequence were comparable to those from the SE technique. In addition, measured lung tissue density and true stiffness values were in agreement with previously reported estimates.

Kevin M. Johnson¹, Scott K. Nagle^1,2, Orhan Unal^1,2, and Sean B. Fain^1,2
1Medical Physics, UW-Madison, Madison, WI, United States, ²Radiology, UW-Madison, Madison, WI, United States

Ultra-short echo time (UTE) imaging holds promise for vastly improved imaging of lung structures but offers little tissue contrast. In this work we investigate the combination of UTE with several conventional echo times and magnetization transfer to separate species based on T2*. Feasibility images were collected in excised swine and human lungs. Ex-vivo images demonstrate successful separation of fluid from short T2* lung tissue and MT effect in all tissue. In human images, short T2* bone and long tissue were separated from long T2 muscle and fat.

Simon Triphan^1,2, Felix A. Breuer¹, Hans-Ulrich Kauczor², and Peter M. Jakob^1,3
1Research Centre Magnetic Resonance Bavaria e.V., Würzburg, Bayern, Germany, ²Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Baden-Württemberg, Germany, ³Experimental Physics 5, University Würzburg, Würzburg, Bayern, Germany

While both T₁ and T₂* are reduced in hyperoxic conditions, these changes reflect different aspects of lung function. A method for measuring both parameters simultaneously using a inversion recovery multi-gradient echo experiment is proposed. By applying an asymmetric radial readout with a golden angle distribution, lung signal is maximised while enabling self-gating to compensate for breathing motion. Since the dc-signal is distorted by the inversion recovery, a correction to recover an undisturbed signal is shown. Generating self-gated parameter maps provides co-registration for T₁ and T₂* maps as well as for maps acquired under different oxygenation conditions.

Weijuan Zhang^1,2, Robert M. Niven^3,4, Simon S. Young⁵, Yuzhen Liu⁵, Penny L. Hubbard^1,2, Geoffrey J. M. Parker^1,2, and Josephine H. Naish^1,2
1Centre of Imaging Sciences, The University of Manchester, Manchester, United Kingdom, ²Biomedical Imaging Institute, The University of Manchester, Manchester, United Kingdom, ³North West Lung Centre, University Hospital of South Manchester, Manchester, United Kingdom, ⁴Department of Respiratory Medicine, University Hospital of South Manchester, Manchester, United Kingdom,⁵Personalised Healthcare and Biomarkers, AstraZeneca, Alderley Park, United Kingdom

This study estimated the feasibility of dynamic OE-MRI in the assessment of lung functional changes in asthmatic patients and explored the correlation between dynamic OE-MRI and spirometry.

André Fischer¹, Christian O. Ritter¹, Stefan Weick², Dietbert Hahn³, and Herbert Köstler^1
1Institute of Radiology, University of Wuerzburg, Wuerzburg, Bavaria, Germany, ²Department of Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany, ³Institute of Radiology, University of Würzburg, Wuerzburg, Bavaria, Germany

This abstract describes the quantification of pulmonary perfusion and ventilation using non-contrast enhanced quasi-randomly acquired DC gated ¹H lung imaging. By properly selecting data according to the DC gating signal which reflects signal variations induced by respiration and pulsatile blood flow, images of the respiratory and cardiac standard cycles are obtained. From these, quantification of perfusion (by a concept called AQUAPICSS) and ventilation (by comparing expiration to inspiration signal levels) is possible. Perfusion rates are in accordance with literature values and additionally performed SEEPAGE experiments. Ventilation rates were derived in normal amplitude respiration and are, therefore, lower than previous literature values obtained in maximum amplitude respiration.

Julius Renne¹, Jens Hohlfeld², Jan Hinrichs¹, Christian Schönfeld¹, Marcel Gutberlet¹, Carla Winkler³, Cornelia Faulenbach², Peter M. Jakob⁴, Norbert Krug², Frank Wacker¹, and Jens Vogel-Claussen^1
1Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany, ²Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany,³Dep. of Pneumology, Hannover Medical School, Hannover, Germany, ⁴Experimental Physics (Biophysics), University of Würzburg, Würzburg, Germany

Endobronchial allergen challenge is an established method for the evaluation of new anti-allergic drugs. Today the concentration of eosinophilic cells is the standard readout parameter for pulmonary inflammation. Therefore repeated bronchoscopies are needed, which are a substantial burden for volunteers. A new method for identification and quantification of the pulmonary inflammation after endobronchial challenge using oxygen-enhanced pulmonary MRI (T1-mapping) is presented.

Gregor Sommer^1,2, Michael Puderbach³, Marcel Koenigkam-Santos^3,4, Christopher Draenkow⁵, Claus-Peter Heussel³, Hans-Ulrich Kauczor⁶, Heinz-Peter Schlemmer², and Grzegorz Bauman^7,8
1Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland, ²Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Radiology, Thoraxklinik Heidelberg, Heidelberg, Germany, ⁴Radiology, University Hospital of the School of Medicine of Ribeirao Preto - University of Sao Paulo, Ribeirao Preto, Brazil, ⁵Surgery, Thoraxklinik Heidelberg, Heidelberg, Germany, ⁶Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany, ⁷Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany,⁸Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States

This study investigates non-contrast-enhanced Fourier decomposition MRI (FD MRI) as a tool for preoperative assessment of regional lung perfusion in 15 patients with NSCLC against dynamic contrast-enhanced MRI (DCE MRI). FD MRI provides high sensitivity (84%), specificity (92%) and accuracy (91%) in detecting lobar perfusion defects. Image quality of FD MRI has shown to be less than that of its reference DCE MRI. FD MRI can quantify bilateral and lobar perfusion proportions with sufficient accuracy in both upper lobes and for bilateral comparison, but is in its present form limited by pulsation artifacts in the lower parts of the lungs.