George Hutchinson¹ and Penny Gowland^1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Diffusion weighted imaging can be used as a marker of altered blood flow through the compromised placenta as the structure of villi is known to change. Probing the size of the intervillous space could provide a useful clinical marker of abnormal development. Here we investigate and demonstrate the effect of changing the encoding time of flow measurements through a porous media, and its ability to provide more information about villous structure.

George Hutchinson¹ and Penny Gowland^1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Analysing diffusion data from the placenta using with biexponential Intravoxel incoherent motion model and an Inverse Laplace approach gave similar final measures for the IVIM fraction and Kurtosis but not for D. 

Jie Li¹, Xiao Ling¹, Tao Wen¹, Rui Wang¹, Zhongping Zhang², Kai Ai³, and Jing Zhang^1
1Lanzhou University second hospital, Lanzhou, China, ²Philips Healthcare, Guangzhou, China, ³Philips Healthcare, Xi'an, China

Estimating placental function is highly desirable, as impaired placental function is associated with FGR and poor neonatal outcome. This study evaluated variations of T2* after oxygen inhalation of 8 pregnant women in the second and third trimesters using quantitative mDixon-Quant imaging. The hyperoxic T2* after oxygen inhalation was significantly higher than baseline T2* which defined as before oxygen inhalation. The change of baseline T2* and hyperoxic T2* was significantly negative correlated with gestational age. The result showed that |△T2*| was correlated with placental function. We speculate T2* based mDixon-Quant imaging is useful in noninvasive assessment of placental function.

Zhijun Ye¹, Gang Ning¹, Xuesheng Li², Qing Li³, Haibo Qu¹, and Thomas Benkert^4
1West China Second University Hospital, Chengdu, China, ²West China Sencond University Hospital, Chengdu, China, ³MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, ⁴MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

This study explored and compared the performance of reduced-FOV diffusion-weighted imaging (rFOV DWI), readout-segmented echo-planar-imaging (rs-EPI) DWI, and conventional single-shot (ss)-EPI DWI techniques for diagnosis of cervical cancer. Image quality was assessed by two radiologists; rFOV DWI and rs-EPI DWI achieved significantly better image quality and clinical utility at both b=50 s/mm2 and b=1000 s/mm2 compared with ss-EPI DWI, and rFOV DWI outperformed rs-EPI DWI in terms of artifacts, overall image quality, and clinical utility.

Cuiping Li¹ and Jiangning Dong^2
1Radiology Department, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science, Hefei, China, ²The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

As the most common histological type in cervical cancer, cervical squamous cell carcinoma (CSCC) mainly affects young women, and most of whom are diagnosed between 35-50 years old. In recent years, studies on tumor biomarkers have continuously increased, Ki-67 was considered as a kind of nuclear protein related to cell proliferation, some previous studies have shown that Ki-67 proliferation index  (PI) is positively correlated with tumor size, invasion, cancer stage and patient survival. In our study work, we investigated the prediction of Ki-67 PI through combining intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) with texture analysis (TA) for CSCC patients. 

Ting-ting Lin¹ and Jiang-ning Dong^2
1Radiology Department, Anhui Provincial Cancer Hospital, Hefei, China, ²Radiology department, Anhui Provincial Cancer Hospital, Hefei, China

The aim of the study was to explore the value of radiomics features based on DCE-MRI in Predicting the  differentiation degree of cervical cancer before treatment. 97 patients pathologically confirmed cervical cancer from March 2017 to December 2018 were enrolled in this study.  The conclusion of radiomics features based on DCE-MRI have good repeatability and are of high value for predicting pre-treatment differentiation of cervical cancer was obtained via the present study.

Xing Meng¹, Ailian Liu¹, Shifeng Tian¹, and Qingwei Song^1
1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China

Diffusion tensor imaging (DTI), as a kind of MR functional imaging, can reflect the direction and free diffusion rate of the diffusion motion of water molecules in voxel. This study intends to investigate the value of endometrial polyp (EP) and endometrial carcinoma (EC) based on quantitative parameters of DTI, in order to improve the accuracy of diagnosis of the two diseases before treatment.

Yuan Wei¹, Shifeng Tian¹, and Ailian Liu^1
1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, China, Dalian City, China, China

Diffusion tensor imaging (DTI) is a functional imaging technology improved and developed on the basis of DWI technology. It reflects the changes of free diffusion rate and direction of water molecules caused by different structures in living tissues. It can obtain multiple quantitative parameters through post-processing. There is no report on the evaluation of endometrial carcinoma (EC) microsatellite instability (MSI) status by DTI quantitative parameters. Results shown that multiple quantitative parameters of DTI were different between MSI and microsatellite stability (MSS) of EC, therefore, it is feasible to use DTI for predicting MSI of EC.

Dahua Cui¹, Ailian Liu¹, Yan Guo², Shifeng Tian¹, and Qingwei Song^1
1The First Affiliated Hospital of Dalian Medical University, Dalian, China, ²GE Healthcare, Shanghai, Shenyang, China

The aim of the study is to explore the value of radiomics approach based on apparent diffusion coefficient (ADC) maps in identifying the pathologic grade of Endometrioid Endometrial Adenocarcinoma (EEA). The AUC of the logistic model based on ADC maps in the testing set was 0.840, sensitivity of 80.0%, specificity of 75.0% and accuracy of 77.5%. The radiomics based on ADC maps has shown a promising identification potential in the pathologic grade of EEA.

Ana E Rodríguez-Soto¹, Star K Huynh², Claire H Meriwether³, Nawal Siddiqui³, Roshan Karunamuni³, Anders M Dale¹, and Rebecca A Rakow-Penner^3
1Radiology, University of California San Diego, La Jolla, CA, United States, ²School of Medicine, University of California San Diego, La Jolla, CA, United States, ³University of California San Diego, La Jolla, CA, United States

Ovarian cancer has a high mortality rate as it is commonly diagnosed in advanced stages. Diffusion weighted imaging (DWI) has shown great promise in detecting cancer in multiple other organs. However, the diffusion characteristics of premenopausal ovaries are difficult to differentiate from malignancies with standard diffusion techniques. In this work we characterized the diffusion properties of ovaries in a group of young women to inform the acquisition and post-processing of DWI to improve ovarian cancer diagnosis.

Yulin Chen¹, Ye Li¹, li Liu¹, Xinliu He¹, Xulun Lu¹, and Ailian Liu^1
1The First Affiliated Hospital of Dalian Medical University, Dalian, Dalian, China

The identification and treatment of ovarian cancer(OC) has always been a problem that plagues us[1]. This worked aimed at exploring the value of Intravoxel incoherent motion (IVIM) quantitative parameters for diagnosis of P53 positive OC.  In contrast, P53 positive and negative OC have large differences in stand ADC values in IVIM. 

Wenjun HU¹, Ailian Liu¹, Ye Li¹, and Qingwei Song^1
1The First Affiliated Hospital of Dalian Medical University, Dalian, China

The aggressiveness level of ovarian tumor is of great importance for clinical treatment and prognosis. The purpose of this study is to explore the value of R2 * in evaluating the aggressiveness of ovarian tumors. The preliminary results showed that the R2 * value of malignant tumors was significantly higher than benign and borderline tumors. R2* is potentially a promising and valuable non-invasive method in evaluating the aggressiveness of ovarian tumors.

Fang Mengshi¹ and Dong Jiangning^2
1Radiology, Anhui Provincial Cancer Hospital, Hefei, China, ²Anhui Provincial Cancer Hospital, Hefei, China

The purpose of our research was to define the possibility of the use of imaging methods to analyze and predict the recent recurrence of ovarian serous carcinoma, with the ultimate hope of helping clinicians to plan more suitable treatments. In our study, in CT and MRI examinations before surgery, peritoneal implantation metastasis and Ki67 PI are suggestive of the possibility of the recurrence of serous ovarian carcinoma in the near future, but other imaging indexes show no obvious value for indicating the possibility of recurrence.

Lisan M. Morsinkhof¹, Jean-Francois Witz², Olivier Mayeur², Anique T.M. Grob³, Frank F.J. Simonis¹, and Pauline Lecomte-Grosbras^2
1Magnetic Detection & Imaging, TechMed Centre, University of Twente, Enschede, Netherlands, ²Laboratoire de mécanique multiphysique multiéchelle, Université de Lille, CNRS, Centrale Lille, Lille, France, ³Multi-Modality Medical Imaging, TechMed Centre, University of Twente, Enschede, Netherlands

Quantitative pelvic organ mobility assessment provides fundamental insight into pelvic organ prolapse (POP). However, this is currently only performed in supine position. In this case study the assessment is performed both in supine and upright position using a tiltable MRI scanner. The displacement of the cervix during contraction is larger in upright than in supine position. During straining the displacement in supine position is 15-20 mm whereas in upright position hardly any displacement occurs. This may indicate that, in upright position, the cervix already reaches its maximum extent at rest. Upright mobility assessment seems to give supplementary information in POP.

Lisan M. Morsinkhof¹, Anique T.M. Grob², Angelique L. Veenstra van Nieuwenhoven³, and Frank F.J. Simonis^1
1Magnetic Detection & Imaging, TechMed Centre, University of Twente, Enschede, Netherlands, ²Multi-Modality Medical Imaging, TechMed Centre, University of Twente, Enschede, Netherlands, ³Department of Gynecology, Ziekenhuisgroep Twente, Almelo/Hengelo, Netherlands

The choice of treatment for pelvic organ prolapse (POP) depends on determining its maximal extent but this might be subject to daily variations. This study uses upright MRI to determine if pelvic organs descend during the day and to make a comparison between women with and without symptomatic POP. For now, only women without POP were scanned three times during one day in supine and upright position. On average the cervix descended during the day and this effect was larger in upright position. A similar effect is expected in patients making the time of staging POP clinically relevant.

Yujiao Zhao¹, wen shen², and cheng zhang^2
1Tianjin first central hospital, tianjin, China, ²Tianjin first central hospital, Tianjin, China

To explore the relationship between pubic injury and levator anal muscle(LAM) injury among primiparas after vaginal delivery. 88 primiparas after vaginal delivery were collected in our study. Two radiologists identified and evaluated the injury condition of pubic and LAM on MR images. The proportion of LAM injury was significantly higher in the pubic injury group than that of in the non-pubic injury group, and the degree of pubic injury was positively correlated with the degree of LAM injury.