ISMRM & SMRT Annual Meeting • 15-20 May 2021

2021 ISMRM & SMRT Annual Meeting Logo Graphic

Member-Initiated Symposium

The Emerging Role of MRI in Gene & Cell Therapy Development

Navigation: Back to Meeting HomeBack to Meeting Home Navigation: Back to Program-at-a-GlanceBack to the Program-at-a-Glance

The Emerging Role of MRI in Gene & Cell Therapy Development
Member-Initiated Symposium
Wednesday, 19 May 2021
Concurrent 8 14:00 -  16:00 Moderators: Jeff Bulte & Nivin Nyström
Session Number: MIS-18
Parent Session: The Emerging Role of MRI in Gene & Cell Therapy Development

Session Number:MIS-18

Organizers
Jeff Bulte, Veronica Clavijo Jordan, Nivin Nyström, Moriel Vandsburger

Overview
This Symposium was proposed by the Molecular & Cellular Imaging study group. Gene and cell therapies are revolutionizing the field of medicine. Prompted by recent successes, the FDA released a report in 2019 predicting that 10-20 gene and cell therapies will be approved each year by 2025. However, basic research and clinical trials have identified numerous systemic and molecular barriers that limit the efficacy of these technologies. Established and upcoming MR methods have much to offer to better understand and overcome these barriers. In our proposed symposium, we would like to introduce the emerging role of MR in the development of gene and cell therapies. It will first feature four talks from a diverse group of senior and junior academic scientists, describing basic principles, challenges, and opportunities of different MR approaches in the context of their own state-of-the-art research. Finally, the head of MR imaging from Pfizer will provide a forward-looking talk that discusses MR, highlighting its strengths and limitations relative to other imaging modalities. Notably, this symposium will include a wide range of technologies and disease models at both preclinical and clinical stages of research. Based on previous years’ programs, we expect that this session will complement content from educational sessions focused on molecular imaging and contrast mechanisms. Ultimately, we hope to educate our attendees on current frameworks of gene and cell therapy research centred around MR imaging and inspire their own studies for this promising field.

Target Audience
Clinicians, basic scientists, engineers, and translational researchers interested in gene and cell therapy development.

Educational Objectives
As a result of attending this course, participants should be able to:
Upon completion of this course, participants should be able to: - Explain the fundamental principles of gene and cell therapies at preclinical and clinical stages of developmen; - Identify current MRI approaches that offer new insights into gene and cell therapy developmen; and - Consider how the attendee’s own research methods can be applied towards better understanding the underlying mechanisms of gene and cell therapies.

      Cell Therapy, Senior Talk: 19F MRI of Dendritic Cell-Based Therapeutics for Rheumatoid Arthritis
Catharien Hilkens
Newcastle University
      Cell Therapy, Junior Talk: MR Imaging of Tumour-Associated Macrophage Changes with Immunotherapy
Fanny Chapelin
University of Kentucky
      Gene Therapy, Senior Talk: MR-Guided Gene Therapy for Parkinson’s Disease
Krzysztof Bankiewicz
Ohio State University
      Gene Therapy, Junior Talk: CEST-MRI of Gene Editing
Bonnie Lam
University of California, Berkeley
      The Industry Perspective
James Goodman
Pfizer

Back to Meeting Home   |   Back to Top

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.