ISMRM & SMRT Annual Meeting • 15-20 May 2021

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Tutorial

Tutorial: Diffusion I & II

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Tutorial: Diffusion I & II
Tutorial
ORGANIZERS: Dmitry Novikov, Markus Nilsson, Mark Does
Saturday, 15 May 2021
Concurrent 1 17:00 -  19:00 Moderators: Dmitry Novikov & Markus Nilsson
Skill Level: Basic to Intermediate
Session Number: T-05
Parent Session: Tutorial: Diffusion I & II

Session Number: T-05

Overview
This course will discuss the foundations of diffusion physics and basic experimental design, followed by an overview of standard representations of diffusion signal and simple models. This educational tutorial session has two distinct features: (1) it has been designed as a coherent course by all the teachers together from the outset, based on the well-attended 2019 Diffusion & Microstructure course; (2) it combines lectures with exercises. For the exercises, which will be given during the lectures and subsequently solved and discussed, please bring paper and pencil. This morning course serves as an introduction to the subsequent advanced microstructure session in the afternoon.

These tutorials will take place in the ISMRM's gather.town Vancouver space, in the Captain George Vancouver Tutorial spaces. You will find those to your left as you enter the Mount Seymour lobby. You can enter ISMRM's gather.town space via the link posted in the session description in Pathable.

Please type in your full name (first name & last name) as you first enter the space so others can recognize you (this is your conference badge!).

At the beginning of the tutorial, please go anywhere in the Tutorial space and join the Zoom call for instructions. You can join the zoom call by clicking "x" as soon as you see a "telephone" sign lighting up yellow. Please note: in some browsers it may be necessary to mute yourself in gather.town as you join the zoom call.

Target Audience
Researchers and clinicians who are interested in understanding the basics of molecular diffusion, designing diffusion experiments, performing basic parameter estimation of standard diffusion metrics (such as DTI and DKI), understanding the difference between biophysical models and signal representations, and gaining intuition into the time-dependent diffusion as a coarse-graining process over the tissue microstructure.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the basic physics of diffusion;
- Describe basic diffusion MRI sequences;
- Compare and contrast biophysical models (e.g., multi-exponential) and signal representations, such as DTI and DKI; and
- Explain the concept of coarse-graining and the associated time-dependence of diffusion metrics.


      Fundamentals of Diffusion

Watch the Video

Marco Palombo
This lecture introduces key concepts behind the physics of dMRI signal contrast, and motivate why these concepts are relevant in the context of quantifying tissue microstructure. Following this lecture, researchers and clinicians who are interested in understanding the basics of molecular diffusion, will gain intuition on the diffusion process as conceptualised by random-walks of particles, familiarise with representing the diffusion process by the diffusion propagator, understand the regimes in which the diffusion can and cannot be considered Gaussian and understand how these concepts are relevant in the context of tissue microstructure. Hands-on exercises will give intuition into the concepts discussed.
      Diffusion MRI: Acquisition
Jana Hutter

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