ISMRM & SMRT Annual Meeting • 15-20 May 2021

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Tutorial

Tutorial: Diffusion III & IV

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Tutorial: Diffusion III & IV
Tutorial
ORGANIZERS: Dmitry Novikov, Markus Nilsson, Mark Does
Sunday, 16 May 2021
Concurrent 1 17:00 -  19:00 Moderators: Dmitry Novikov & Markus Nilsson
Session Number: T-12
Parent Session: Tutorial: Diffusion III & IV

Session Number: T-12

Overview
This course will discuss the foundations of diffusion physics and basic experimental design, followed by an overview of standard representations of diffusion signal and simple models. This educational tutorial session has two distinct features: (1) it has been designed as a coherent course by all the teachers together from the outset, based on the well-attended 2019 Diffusion & Microstructure course; (2) it combines lectures with exercises. For the exercises, which will be given during the lectures and subsequently solved and discussed, please bring paper and pencil. This morning course serves as an introduction to the subsequent advanced microstructure session in the afternoon.

These tutorials will take place in the ISMRM's gather.town Vancouver space, in the Captain George Vancouver Tutorial spaces. You will find those to your left as you enter the Mount Seymour lobby. You can enter ISMRM's gather.town space via the link posted in the session description in Pathable.

Please type in your full name (first name & last name) as you first enter the space so others can recognize you (this is your conference badge!).

At the beginning of the tutorial, please go anywhere in the Tutorial space and join the Zoom call for instructions. You can join the zoom call by clicking "x" as soon as you see a "telephone" sign lighting up yellow. Please note: in some browsers it may be necessary to mute yourself in gather.town as you join the zoom call.

Target Audience
Researchers and clinicians who are interested in understanding the basics of molecular diffusion, designing diffusion experiments, performing basic parameter estimation of standard diffusion metrics (such as DTI and DKI), understanding the difference between biophysical models and signal representations, and gaining intuition into the time-dependent diffusion as a coarse-graining process over the tissue microstructure.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the basic physics of diffusion;
- Describe basic diffusion MRI sequences;
- Compare and contrast biophysical models (e.g., multi-exponential) and signal representations, such as DTI and DKI; and
- Explain the concept of coarse-graining and the associated time-dependence of diffusion metrics.
 


      Diffusion MRI: Models & Representations
Chantal Tax
      Microstructure Modeling

Watch the Video

Hong-Hsi Lee
Diffusion MRI enables to estimate microstructural length scale in cell dimension. Here we introduce three common examples in biophysical modeling of diffusion MRI: (1) Considering diffusion dephasing as transverse relaxation due to field inhomogeneity of applied diffusion gradient, intra-cellular signals mainly depend on gradient pulse duration in wide pulse limit. (2) The diffusion time-dependence in a heterogeneous medium is a process of spatial homogenization of restrictions, leading to power-law tails in diffusivity time-dependence. (3) Directional average of signals for each diffusion weighting b and the analysis of its deviations from 1/√b scaling provides a rotationally invariant axon size estimation.

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