ISMRM21 - Multinuclear Imaging & Spectroscopy

Multinuclear Imaging & Spectroscopy

Sunrise Session

ORGANIZERS: Eva-Maria Ratai, Duan Xu, Xin Yu, Malgorzata Marjanska

Sunday, 16 May 2021

Concurrent 2

13:00 - 13:45

Moderators: Ilwoo Park & Rita Schmidt

Skill Level: Intermediate to Advanced

Session Number: WE-19

Parent Session: Basic MR Spectroscopy

Session Number: WE-19

Overview
This is a sunrise educational series on multi-nuclear imaging and spectroscopy.

This course will discuss the current progress of hyperpolarized carbon-13 imaging in clinical research and trials; identify current obstacles to hyperpolarized 13C MRI for widespread clinical use, and provide recommendations for overcoming them; and review the existing MR imaging methods for 23Na-MRI for (clinical) research. It will then introduce emerging (clinical) applications to study cell membrane potentials and tissue integrity in healthy tissue, pathologic states, and as a way to monitor treatment response. Lastly, this course will discuss the emerging technique of deuterium metabolic imaging (DMI), including its clinical applications. DMI is a novel, noninvasive approach that combines deuterium magnetic resonance spectroscopic imaging with oral intake or intravenous infusion of nonradioactive 2H-labeled substrates to generate three-dimensional metabolic maps.

Target Audience
MR scientists, MR technologists, clinicians, and scientists interested in performing hyperpolarized 13C studies clinically, 23Na-MRI, and 2H-MRS.

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify the requirements of implementing these techniques;
- Explain the current progress of hyperpolarized 13C imaging, 23Na imaging, and deuterium metabolic imaging (DMI) in clinical research applications; and
- Recognize the challenges and the pros and cons of these data acquisitions.

		Hyperpolarized 13C: Principles & Clinical Applications Watch the Video Mary McLean Hyperpolarization of ¹³C can transiently increase its signal around 100,000 fold. This enables tracer studies in vivo of ¹³C-labelled metabolites with high time resolution. The polarization decays with a T₁ of around 30 s, necessitating innovations in hardware, sequences, and study design to capture the signal within its short longevity. The first tracer molecule taken into humans has been [1-¹³C]pyruvate. Metabolism to lactate, alanine, and bicarbonate has been shown in human brain, heart, muscle, and abdominal organs. Much interest has focused on studies in cancer, where elevations in lactate labelling related to the Warburg effect can be observed.
		Basic Understanding & Clinical Applications of 23Na-MRI Watch the Video Sandro Romanzetti Sodium is the second most abundant MR active nucleus in the human body and it has a fundamental role in the physiology of human cells. Nevertheless, its low concentration and quick relaxation have limited its application in medicine for a very long time. Research from the last two decades has shown that sodium MRI is no longer a novel MR method. Most of the challenges associated with its application have been addressed. Furthermore, the increasing availability of ultra-high field MR systems (UHF-MRI) in clinical settings has opened new horizons for many medical applications of Sodium MRI.
		Deuterium Metabolic Imaging (DMI) Watch the Video Xiao-Hong Zhu Metabolic imaging provides valuable tools for evaluating cellular metabolism under physiopathological conditions. Deuterium metabolic imaging (DMI) is a newly developed deuterium (²H) MRS imaging technology that can measure the steady-state signal and/or dynamic changes of deuterated metabolites in living organs or tissues after administration of deuterium-labeled substrate. DMI has been used to study various metabolic processes, especially the cerebral glucose metabolism in healthy brain and in brain tumor patients, and has shown its advantages over certain existing methods. This presentation will briefly introduce DMI technology - its past development, current capabilities and future prospects.