 |
PROGRAM |
Educational Objectives:
Upon completion of this workshop, participants should be able to:
- Identify the biochemical assumptions, metabolic
modeling and MR spectroscopic methods utilized to measure
neurotransmitter metabolism and the metabolic coupling between
neuronal and glial cells:
- Discuss the relationship between neuronal activity,
cerebral blood flow, oxidative metabolism, BOLD fMRI and electrical
activity in the brain and how they can be measured using MR
spectroscopy and imaging;
- Discuss how MR spectroscopy can be used to quantify
the flux through major metabolic pathways in the liver, and their
relationship to diabetes;
- Describe the methodology and assumptions underlying
MR measurements of intra-myocellular and intra-hepatic lipids and
their role in the development of obesity and diabetes;
- Describe how MR spectroscopy and imaging can be
used to identify ischemic heart disease.
|
|
|
Friday, 5 September |
17:00-19:00 |
Registration |
|
Saturday, 6
September |
|
Brain Function and Metabolism |
|
08:00 |
Welcome and Introduction
Hoby P. Hetherington, Ph.D., Albert Einstein College of
Medicine, Bronx, NY, USA |
|
Session I: Brain Metabolism Neuronal/Glial
Coupling and Neurotransmission
Chair: Brian D. Ross, M.D., Ph.D., Huntington Medical Research
Institute, Pasadena, CA, USA |
08:05 |
Introduction
Brian D. Ross, M.D., Ph.D., Huntington Medical Research Institute,
Pasadena, CA, USA |
|
08:15 |
Brain Metabolism: Evidence of Neuronal/Glial Coupling
Dr. Igor Allaman, Institut de Physiologie, Lausanne, Switzerland |
|
08:45 |
Modeling Metabolic Turnover, Flux and Compartmentation
Pierre-Gilles Henry, Ph.D., CMRR, University of Minnesota, Minneapolis, MN,
USA |
|
09:15 |
Metabolic Turnover Measuring Neuronal Glial Cycling
Kevin L. Behar, Ph.D., Yale University School of Medicine, New Haven,
CT, USA |
|
09:45 |
Alternative Fuels for Oxidative Metabolism in the Human Brain
Jullie W. Pan, M.D., Ph.D., Albert
Einstein College of Medicine, Bronx, NY, USA |
|
10:15 |
Break |
Oral Session: Cerebral Metabolism in Normal and
Pathological States
Submitted Presentations: |
|
10:45 |
Anaplerosis in the Human Brain
Graeme F. Mason |
|
11:00 |
Abnormal Glutamate Neurotransmission Observed by 13C
MRS in Patients with Adult Polyglucosan Storage Disease
Alexander Lin |
|
11:15 |
Regional differences in the effects of isoflurane on
neurotransmitter metabolism
P.N. Venkatasubramanian |
|
11:30 |
Improved Sensitivity in an NMR-based Measurement of Glucose
Metabolism in Rat Brain Using [6-13C]2-Deoxyglucose
David M. Cohen |
|
11:45 |
Development of in vivo 13C MRS to study
alterations in glucose uptake and neurotransmitter metabolism in CK
deficient mouse brain
W. Klaas J. Renema |
|
12:00 |
Break |
Session II: The Coupling Between Brain Function,
Physiology, and Metabolism
Chair: Richard P. Kennan, Ph.D.,
Albert Einstein College of Medicine, Bronx, NY, USA |
|
13:30 |
Introduction
Richard P. Kennan, Ph.D., Albert
Einstein College of Medicine, Bronx, NY, USA |
|
13:40 |
Brain Function and Oxidative Metabolism: Neuroiming with fMRI
Fahmeed Hyder, Ph.D., Yale University School of Medicine, New Haven,
CT, USA |
|
14:10 |
CMRO2 and Functional Activity Mapped by 17O
NMR
Wei Chen, Ph.D., CMRR, University of Minnesota,
Minneapolis, MN, USA |
|
14:40 |
The Relationship between CBF, BOLD, and Functional Activity
Seong-Gi Kim, Ph.D., University of Pittsburgh Imaging Center,
Pittsburgh, PA, USA |
|
15:10 |
fMRI of Primates: Goals and Hurdles
Paul Gamlin and Donald B. Twieg, Ph.D., University of Alabama,
Birmingham, AL, USA |
|
15:40 |
Break |
Oral Session: The Best of the Rest in the Brain
Submitted Presentations: |
|
16:00 |
Susceptibility Imaging in Acute Ischemia with 3D LASER-EPI
Simona Nikolova |
|
16:15 |
Bayesian Probability Theory Applied to MR Data Analysis
Joseph J.H. Ackerman |
|
16:30 |
Abnormal brain 1H MRS may be predictive of
Lipodystrophy (L+) in HIV positive patients (HIV+)
Alexander Lin |
|
16:45 |
The relationship of the diffusion coefficient of N-acetylaspartate
and magnetic field strength
David N. Guilfoyle |
|
17:00 |
Adjournment |
|
Sunday, 7 September |
|
Liver and Skeletal Muscle Metabolism: Applications to
Diabetes and Obesity |
Session III: Liver and Skeletal Muscle Metabolism: Methods
and Basic Mechanisms
Chair: Gerald I. Shulman, M.D., Ph.D., Howard Hughes Medical
Institute-Yale, New Haven, CT, USA |
|
08:00 |
Introduction
Gerald I. Shulman, M.D., Ph.D., Howard Hughes Medical Institute-Yale,
New Haven, CT, USA |
|
08:10 |
Overview of Diabetes and Metabolism
Roy Taylor, M.D., Newcastle upon Tyne, England, UK |
|
08:40 |
MR Tools for Assessing Liver Metabolism and Function in
Diabetes
Douglas L. Rothman, Ph.D., Yale University School of Medicine, New
Haven, CT, USA |
|
09:10 |
Substrate Selection and Metabolic Flux in the Liver
Craig Malloy, M.D., UT Southwestern Medical Center, Dallas, TX, USA |
|
09:40 |
Role of Glycogen in Diabetes
Kitt M. F. Petersen, Yale University School of Medicine, New Haven,
CT, USA |
|
10:20 |
Break |
Oral Session: Metabolism and Physiology: Relationship to
Diabetes and Obesity
Submitted Presentations |
|
10:40 |
Hepatic Glucose Metabolism during Combined Hyperinsulinemia
and Hyperglycemia in Type 2 Diabetes
Martin Krssak |
|
10:55 |
Effects of short-duration skeletal muscle exercise on
glycogen synthesis in obesity during hyperinsulinemia. A study using
13C magnetic resonance spectroscopy
Jacco H. de Haan |
|
11:10 |
Liver Flux Profile of the Isolated Perfused C57B1/6 Mouse
Liver
Natasha L. Hausler |
|
11:25 |
In vivo measurement of lipids in mice
Joel R. Garbow |
|
11:40 |
MRS based metabolic study on ischemic preconditioning in
steatotic livers after cold ischemia in the rat
Natalie J. Serkova |
|
11:55 |
Clinical Oximetry using EPR - Direct measurements of tissue
oxygen in diabetic peripheral vascular disease
Harold M. Swartz |
|
12:10 |
Break |
|
Session IV: Liver and Skeletal Muscle Metabolism:
Applications to Diabetes and Obesity |
|
13:30 |
Introduction |
|
13:40 |
Methods and Basis for Measuring IMCL
Peter Vermathen, Ph.D., Inselspital and University, Bern, Switzerland |
|
14:10 |
Multi-Nuclear Studies for Insulin Resistance
Michael Roden, M.D., University of Vienna School of Medicine, Vienna,
Austria |
|
14:40 |
Hepatic and Intramyocellular Lipids and Diabetes
Jong-Hee Hwang, Ph.D., Albert
Einstein College of Medicine, Bronx, NY, USA |
|
15:10 |
IMCL and Obesity
Gianluca Persghin, M.D., Instituto Scientifico, Universitario San
Raffaele, Milan, Italy |
|
15:40 |
Break |
Oral Session: Skeletal Muscle Energetics, Physiology and
Function
Submitted Presentations |
|
16:00 |
Improved energetic status of skeletal muscle during ischemia
and reperfusion followed by in vivo and in vitro 31P
Magnetic Resonance Spectroscopy
Bassam Soussi |
|
16:15 |
Effects of creatine supplementation on phosphorylated
guanidinoacetate recovery after ischemia in creatine deficient knockout mice
Hermien E. Kan |
|
16:30 |
13C MRS for the direct detection of the
phosphocreatine and creatine ratio and the local creatine turnover rate in
skeletal muscle
Marinette van der Graaf |
|
16:45 |
Multiparametric functional NMR of muscle perfusion,
oxygenation and energetic metabolism: determination of relevant
physiological pattern differences in two groups of elite sportmen trained in
endurance and sprint
S. Duteil |
|
17:00 |
A Pharmokinetic Study of Trifluoperazine Crossing
Blood-Brain-Barrier Due to P-glycoprotein Modulation
Paul C. Wang |
|
17:15 |
Towards a Theoretical Understanding of Muscle Functional MRI
Bruce M. Damon |
|
17:30 |
Adjournment |
|
Monday, 8 September |
|
Cardiac Metabolism and Ischemia |
|
Session V: Metabolism and Function
in the Heart: In Vivo Detection of Ischemia
Chair: Jan den Hollander, Ph.D., University of Alabama at
Birmingham, Center for NMR Research & Development, Birmingham, AL, USA |
|
08:00 |
Introduction
Jan den Hollander, Ph.D., University of Alabama at Birmingham, Center
for NMR Research & Development, Birmingham, AL, USA |
|
08:10 |
Metabolism and Cardiac Function
James A. Balschi, Ph.D., Brigham and Women's Hospital, Boston, MA, USA |
|
08:40 |
Cardiac Physiology: Oxygen and Related Parameters
Harold M. Swartz, M.D., Ph.D., Dartmouth Medical School, Hanover, NH,
USA |
|
9:10 |
MR Functional Measures of the Heart
Han Wen, Ph.D., National Institutes of Health, Bethesda, MD, USA |
|
09:40 |
31P Spectroscopy and Cardiac Ischemia
Stephen D. Buchthal, Ph.D., University of Alabama, Birmingham, AL, USA |
|
10:00 |
Break |
Oral Session: Cardiac Energetics, Metabolism and Function
Submitted Presentations |
|
10:30 |
Clinical and Basic Studies of 31P MR Spectroscopy
with Myocardial Infarction and Reperfusion
Fabao Gao |
|
10:45 |
A New Approach to Detect Myocardial Ischemia and its Cause by
MRS
Saryu Singh |
|
11:00 |
Detection of Myocardial Triglycerides in C57B1/6 Mice by NMR
Kimberly A. Rosaeen |
|
11:15 |
13C Isotopomer Analysis of Hearts Perfused with
Glucose Reveals Active Pyruvate Cycling
A. Dean Sherry |
|
11:30 |
Determining Cardiac Dynamics and Myocardial Morphology from
DENSE MRI Data
Nikoo Saber |
|
11:45 |
Efficacy of MR Asynchrony Indices of Disconjugate Cardiac
Contractility (DCC)
Andrew S. Lee |
|
12:00 |
Adjournment |
|
 |